6-hydroxychromone-hydrazone-Cpd3e
IC50 microM hCA I 4.39 +/- 0.05; hCA II 2.46 +/- 0.10; AChE 0.20 +/- 0.01; Ki microM hCA I 6.14 +/- 0.41; hCA II 5.87 +/- 1.50; AChE 0.08 +/- 0.01; Antioxidant IC50 (microg mL1) DPPH 4.17 +/- 0.02; ABTS 2.46 +/- 0.03
General
Type : Multitarget, Carbonic anhydrase inhibitor, Chromen, Coumarin, Naphthalen, Hydrazide
Chemical_Nomenclature : (E)-3-Hydroxy-N-((6-hydroxy-4-oxo-4H-chromen-3-yl)methylene)-2-naphthohydrazide
Canonical SMILES : C2(=COC1=CC=C(C=C1C2=O)O)C=NNC(C3=CC4=C(C=C3O)C=CC=C4)=O
InChI : InChI=1S\/C21H14N2O5\/c24-15-5-6-19-17(9-15)20(26)14(11-28-19)10-22-23-21(27)16-7-12-3-1-2-4-13(12)8-18(16)25\/h1-11,24-25H,(H,23,27)
InChIKey : DWDSECLPLFQUCA-UHFFFAOYSA-N
Other name(s) : Compound 3e
Target
Families : 6-hydroxychromone-hydrazone-Cpd3e ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis, multi-target evaluation and DFT analysis of 6-hydroxychromone derived hydrazones with carbonic anhydrase I-II\/acetylcholinesterase inhibition and antioxidant activity - Zareen_2026_RSC.Adv_16_8807 |
| Author(s) : Zareen W , Ahmed N , Tokali FS , Islam T , Al-Rashida M , Senol AM , Ulucay O , Tawfeek AM , Taslimi P , Shafiq Z , Islam MS |
| Ref : RSC Adv , 16 :8807 , 2026 |
| Abstract : |
| PubMedSearch : Zareen_2026_RSC.Adv_16_8807 |
| PubMedID: 41695418 |