A1BK4
General
Type : Peptide
Chemical_Nomenclature : N-(dihydroxymethyl)-L-phenylalanyl-N-[(2R,3S)-2-hydroxy-1-methoxy-5-methyl-1-oxohexan-3-yl]-L-lysinamide
Canonical SMILES : (C)C[C@@H]([C@H](C(=O)OC)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(O)O
InChI : InChI=1S\/C24H40N4O7\/c1-15(2)13-18(20(29)23(32)35-3)27-21(30)17(11-7-8-12-25)26-22(31)19(28-24(33)34)14-16-9-5-4-6-10-16\/h4-6,9-10,15,17-20,24,28-29,33-34H,7-8,11-14,25H2,1-3H3,(H,26,31)(H,27,30)\/t17-,18-,19-,20+\/m0\/s1
InChIKey : FKYXTMPITQBLQQ-LWYYNNOASA-N
Other name(s) : (5S,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-isobutyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate || methyl (2~{R},3~{S})-3-[[(2~{S})-6-azanyl-2-[[(2~{S})-2-[bis(oxidanyl)methylamino]-3-phenyl-propanoyl]amino]hexanoyl]amino]-5-methyl-2-oxidanyl-hexanoate
Target
Families : A1BK4 ligand of proteins in family
Tiancimycin-TnmK-Tripeptidase-HIP
Structure :
9MD7
Protein :
myctu-ym24
References (3)
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |
| Title : Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis - Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| Author(s) : Schumann N , Shamma F , Brooks CL , Johnson SJ , Yim MK , Olsen KJ , Pena K , Karakousis PC , Abell A , Goldfarb NE |
| Ref : Eur J Med Chem Rep , 15 :100311 , 2025 |
| Abstract : |
| PubMedSearch : Schumann_2025_Eur.J.Med.Chem.Rep_15_100311 |
| PubMedID: |