Acetyl-methoxyphenyl-fluorobenzyl-methyl-carbamate-D12
hBuChE IC50 = 81 nM and hFFAH IC50 = 400 nM
General
Type : Multitarget, Carbamate, FAAH inhibitor
Chemical_Nomenclature : 2-acetyl-5-methoxyphenyl (4-fluorobenzyl)(methyl)carbamate
Canonical SMILES : C1=C(C(=CC(=C1)OC)C(C)=O)OC(=O)N(C)CC2=CC=C(C=C2)F
InChI : InChI=1S\/C18H18FNO4\/c1-12(21)16-10-15(23-3)8-9-17(16)24-18(22)20(2)11-13-4-6-14(19)7-5-13\/h4-10H,11H2,1-3H3
InChIKey : NBGAOYOHAXLXEP-UHFFFAOYSA-N
Other name(s) : D12
Target
Families : Acetyl-methoxyphenyl-fluorobenzyl-methyl-carbamate-D12 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Natural phenol carbamates: Selective BuChE\/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model - Rong_2024_Eur.J.Med.Chem_281_117003 |
| Author(s) : Rong K , Li Z , Wu X , Gao S , Zhao J , Yang J , Jiang X , Zhang J , Tang W |
| Ref : Eur Journal of Medicinal Chemistry , 281 :117003 , 2024 |
| Abstract : |
| PubMedSearch : Rong_2024_Eur.J.Med.Chem_281_117003 |
| PubMedID: 39481228 |