Aromatic-tertiary-amine-17c

IC50 eqBChE 0.22 +/- 0.018 microM, IC50 human-BCHE 0.016 +/- 0.006 microM

General

Type : Naphthalen, Carboxamide

Chemical_Nomenclature : N-(2-methylphenyl)-2-[2-methylpropyl(naphthalen-2-ylmethyl)amino]acetamide

Canonical SMILES : CC1=CC=CC=C1NC(=O)CN(CC2=CC3=CC=CC=C3C=C2)CC(C)C

InChI : InChI=1S\/C24H28N2O\/c1-18(2)15-26(17-24(27)25-23-11-7-4-8-19(23)3)16-20-12-13-21-9-5-6-10-22(21)14-20\/h4-14,18H,15-17H2,1-3H3,(H,25,27)

InChIKey : ULIOAMNTKXKLNZ-UHFFFAOYSA-N

Other name(s) : 2-(isobutyl (naphthalen-2-ylmethyl)amino)-N-(o-tolyl)acetamide, 17c


MW : 360.5

Formula : C24H28N2O

CAS_number :

PubChem : 156786229

UniChem : ULIOAMNTKXKLNZ-UHFFFAOYSA-N

Target

Families : Aromatic-tertiary-amine-17c ligand of proteins in family
BCHE

Protein :
human-BCHE

References (1)

Title : Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease - Lu_2022_Eur.J.Med.Chem_243_114729
Author(s) : Lu X , Qin N , Liu Y , Du C , Feng F , Liu W , Chen Y , Sun H
Ref : Eur Journal of Medicinal Chemistry , 243 :114729 , 2022
Abstract :
PubMedSearch : Lu_2022_Eur.J.Med.Chem_243_114729
PubMedID: 36084535