Avicine
Avicine Ki 0.063 microM (EeAChE), 0.511 microM (HrAChE) and 0.123 microM (EqBChE)
General
Type : Alkaloid, Natural, Phenanthrene, Benzodioxo, Phenanthridinium
Chemical_Nomenclature : 12-methyl-5,7,17,19-tetraoxa-12-azoniahexacyclo[11.11.0.02,10.04,8.014,22.016,20]tetracosa-1(13),2,4(8),9,11,14,16(20),21,23-nonaene
Canonical SMILES : C[N+]1=CC2=CC3=C(C=C2C4=C1C5=CC6=C(C=C5C=C4)OCO6)OCO3
InChI : InChI=1S\/C20H14NO4\/c1-21-8-12-5-17-18(24-10-23-17)6-14(12)13-3-2-11-4-16-19(25-9-22-16)7-15(11)20(13)21\/h2-8H,9-10H2,1H3\/q+1
InChIKey : IUMDBPMWPHHBDU-UHFFFAOYSA-N
Other name(s) : RefChem:1077371 || CHEMBL5181238 || SCHEMBL13170174 || BDBM50591665 || 1,3-Benzodioxolo[5,6-c][1,3]dioxolo[4,5-j]phenanthridinium, 5-methyl-
Target
Families : Avicine ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (3)
| Title : Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Abeta(1-42) aggregation - Plazas_2020_Bioorg.Chem_98_103722 |
| Author(s) : Plazas E , Hagenow S , Avila Murillo M , Stark H , Cuca LE |
| Ref : Bioorg Chem , 98 :103722 , 2020 |
| Abstract : |
| PubMedSearch : Plazas_2020_Bioorg.Chem_98_103722 |
| PubMedID: 32155491 |
| Title : Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Abeta(1-42) aggregation - Plazas_2020_Bioorg.Chem_98_103722 |
| Author(s) : Plazas E , Hagenow S , Avila Murillo M , Stark H , Cuca LE |
| Ref : Bioorg Chem , 98 :103722 , 2020 |
| Abstract : |
| PubMedSearch : Plazas_2020_Bioorg.Chem_98_103722 |
| PubMedID: 32155491 |
| Title : Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Abeta(1-42) aggregation - Plazas_2020_Bioorg.Chem_98_103722 |
| Author(s) : Plazas E , Hagenow S , Avila Murillo M , Stark H , Cuca LE |
| Ref : Bioorg Chem , 98 :103722 , 2020 |
| Abstract : |
| PubMedSearch : Plazas_2020_Bioorg.Chem_98_103722 |
| PubMedID: 32155491 |