BChE-IN-21
BChE-IN-21 is a potent BChE inhibitor with an IC50 of 0.14 +/- 0.02 microM
General
Type : Pyridine, Quinoline, Carboxamide
Chemical_Nomenclature : N-[[1-[(4-bromophenyl)methyl]pyridin-1-ium-3-yl]methyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide
Canonical SMILES : COC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NCC4=C[N+](=CC=C4)CC5=CC=C(C=C5)Br
InChI : InChI=1S\/C30H24BrN3O2\/c1-36-25-14-10-23(11-15-25)29-17-27(26-6-2-3-7-28(26)33-29)30(35)32-18-22-5-4-16-34(20-22)19-21-8-12-24(31)13-9-21\/h2-17,20H,18-19H2,1H3\/p+1
InChIKey : VYGKYAZJGZVESJ-UHFFFAOYSA-O
Other name(s) : HY-155369 || CS-0901330 || 7n
MW : 619.3
Formula : C30H25Br2N3O2
CAS_number :
PubChem : 169450256, 169450257
UniChem : VYGKYAZJGZVESJ-UHFFFAOYSA-O
Target
Families : BChE-IN-21 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Phenyl-quinoline derivatives as a lead structure of cholinesterase inhibitor endowed with potency to reduce the GSK-3beta level targeting Alzheimer's disease - Noori_2023_Int.J.Biol.Macromol__127392 |
| Author(s) : Noori M , Dastyafteh N , Safapoor S , Ghomi MK , Tanideh R , Zomorian K , Hamedifar H , Dara M , Zare S , Irajie C , Javanshir S , Rastegar H , Panahi N , Larijani B , Mahdavi M , Hajimiri MH , Iraji A |
| Ref : Int J Biol Macromol , :127392 , 2023 |
| Abstract : |
| PubMedSearch : Noori_2023_Int.J.Biol.Macromol__127392 |
| PubMedID: 37827412 |