Benactyzine
Centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression. Competitive inhibitor of BChE Ki values of 0.010 +/- 0.001
General
Type : Not AlphaBeta Hydrolase target, Muscarinic antagonist
Chemical_Nomenclature : 2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate
Canonical SMILES : CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O
InChI : InChI=1S\/C20H25NO3\/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18\/h5-14,23H,3-4,15-16H2,1-2H3
InChIKey : IVQOFBKHQCTVQV-UHFFFAOYSA-N
Other name(s) : Benactyzin || 2-Diethylaminoethyl benzilate || Diethylaminoethyl benzilate || CHEMBL70352 || SCHEMBL49077 || CHEBI:94775 || DB09023
MW : 327.4
Formula : C20H25NO3
CAS_number : 302-40-9
PubChem : 9330
UniChem : IVQOFBKHQCTVQV-UHFFFAOYSA-N
Target
Families : Benactyzine ligand of proteins in family
BCHE
Protein :
human-BCHE
References (8)
| Title : Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote - Weitman_2022_Sci.Rep_12_18078 |
| Author(s) : Weitman M , Eisenkraft A , Tashma Z , Makarovsky I , Last D , Daniels D , Guez D , Shneor R , Mardor Y , Nudelman A , Krivoy A |
| Ref : Sci Rep , 12 :18078 , 2022 |
| Abstract : |
| PubMedSearch : Weitman_2022_Sci.Rep_12_18078 |
| PubMedID: 36302937 |
| Title : Efficacy of antidotal treatment against sarin poisoning: the superiority of benactyzine and caramiphen - Raveh_2008_Toxicol.Appl.Pharmacol_227_155 |
| Author(s) : Raveh L , Rabinovitz I , Gilat E , Egoz I , Kapon J , Stavitsky Z , Weissman BA , Brandeis R |
| Ref : Toxicol Appl Pharmacol , 227 :155 , 2008 |
| Abstract : |
| PubMedSearch : Raveh_2008_Toxicol.Appl.Pharmacol_227_155 |
| PubMedID: 18320638 |
| Title : Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase - Bodur_2001_Arch.Biochem.Biophys_386_25 |
| Author(s) : Bodur E , Cokugras AN , Tezcan EF |
| Ref : Archives of Biochemistry & Biophysics , 386 :25 , 2001 |
| Abstract : |
| PubMedSearch : Bodur_2001_Arch.Biochem.Biophys_386_25 |
| PubMedID: 11360997 |
| Title : Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats - Kassa_1997_Hum.Exp.Toxicol_16_563 |
| Author(s) : Kassa J , Fusek J |
| Ref : Hum Exp Toxicol , 16 :563 , 1997 |
| Abstract : |
| PubMedSearch : Kassa_1997_Hum.Exp.Toxicol_16_563 |
| PubMedID: 9363473 |
| Title : [Comparison of the effect of HI-6 oxime and its derivatives in combination with benactyzine on cholinergic and stress effects of soman in rats]. [Czech] - Kassa_1996_Ceska.Slov.Farm_45_149 |
| Author(s) : Kassa J |
| Ref : Ceska a Slovenska Farmacie , 45 :149 , 1996 |
| Abstract : |
| PubMedSearch : Kassa_1996_Ceska.Slov.Farm_45_149 |
| PubMedID: 8696692 |
| Title : The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor - Amitai_1987_Mol.Pharmacol_32_678 |
| Author(s) : Amitai G , Herz JM , Bruckstein R , Luz-Chapman S |
| Ref : Molecular Pharmacology , 32 :678 , 1987 |
| Abstract : |
| PubMedSearch : Amitai_1987_Mol.Pharmacol_32_678 |
| PubMedID: 3683366 |
| Title : Comparative effects of aprophen, atropine and benactyzine on central and peripheral cholinoceptors and on acetylcholinesterase - |
| Author(s) : Dawson RM , Freeman SE , Paddle BM |
| Ref : Biochemical Pharmacology , 34 :1577 , 1985 |
| PubMedID: 3994766 |