Benactyzine

Centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression. Competitive inhibitor of BChE Ki values of 0.010 +/- 0.001

General

Type : Not A\/B H target, Muscarinic antagonist

Chemical_Nomenclature : 2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate

Canonical SMILES : CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O

InChI : InChI=1S\/C20H25NO3\/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18\/h5-14,23H,3-4,15-16H2,1-2H3

InChIKey : IVQOFBKHQCTVQV-UHFFFAOYSA-N

Other name(s) : Benactyzin  ||  2-Diethylaminoethyl benzilate  ||  Diethylaminoethyl benzilate  ||  CHEMBL70352  ||  SCHEMBL49077  ||  CHEBI:94775  ||  DB09023


MW : 327.4

Formula : C20H25NO3

CAS_number : 302-40-9

PubChem : 9330

UniChem : IVQOFBKHQCTVQV-UHFFFAOYSA-N

Target

Families : Benactyzine ligand of proteins in family
BCHE

Protein :
human-BCHE

References (8)

Title : Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote - Weitman_2022_Sci.Rep_12_18078
Author(s) : Weitman M , Eisenkraft A , Tashma Z , Makarovsky I , Last D , Daniels D , Guez D , Shneor R , Mardor Y , Nudelman A , Krivoy A
Ref : Sci Rep , 12 :18078 , 2022
Abstract :
PubMedSearch : Weitman_2022_Sci.Rep_12_18078
PubMedID: 36302937

Title : Efficacy of antidotal treatment against sarin poisoning: the superiority of benactyzine and caramiphen - Raveh_2008_Toxicol.Appl.Pharmacol_227_155
Author(s) : Raveh L , Rabinovitz I , Gilat E , Egoz I , Kapon J , Stavitsky Z , Weissman BA , Brandeis R
Ref : Toxicol Appl Pharmacol , 227 :155 , 2008
Abstract :
PubMedSearch : Raveh_2008_Toxicol.Appl.Pharmacol_227_155
PubMedID: 18320638

Title : Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase - Bodur_2001_Arch.Biochem.Biophys_386_25
Author(s) : Bodur E , Cokugras AN , Tezcan EF
Ref : Archives of Biochemistry & Biophysics , 386 :25 , 2001
Abstract :
PubMedSearch : Bodur_2001_Arch.Biochem.Biophys_386_25
PubMedID: 11360997

Title : Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats - Kassa_1997_Hum.Exp.Toxicol_16_563
Author(s) : Kassa J , Fusek J
Ref : Hum Exp Toxicol , 16 :563 , 1997
Abstract :
PubMedSearch : Kassa_1997_Hum.Exp.Toxicol_16_563
PubMedID: 9363473

Title : [Comparison of the effect of HI-6 oxime and its derivatives in combination with benactyzine on cholinergic and stress effects of soman in rats]. [Czech] - Kassa_1996_Ceska.Slov.Farm_45_149
Author(s) : Kassa J
Ref : Ceska a Slovenska Farmacie , 45 :149 , 1996
Abstract :
PubMedSearch : Kassa_1996_Ceska.Slov.Farm_45_149
PubMedID: 8696692

Title : The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor - Amitai_1987_Mol.Pharmacol_32_678
Author(s) : Amitai G , Herz JM , Bruckstein R , Luz-Chapman S
Ref : Molecular Pharmacology , 32 :678 , 1987
Abstract :
PubMedSearch : Amitai_1987_Mol.Pharmacol_32_678
PubMedID: 3683366

Title : Comparative effects of aprophen, atropine and benactyzine on central and peripheral cholinoceptors and on acetylcholinesterase -
Author(s) : Dawson RM , Freeman SE , Paddle BM
Ref : Biochemical Pharmacology , 34 :1577 , 1985
PubMedID: 3994766

Title : Therapeutic effects of new oximes, benactyzine and atropine in Soman poisoning: Part I. Effects of various oximes in Soman, Sarin, and Vx poisoning in dogs -
Author(s) : Weger N , Szinicz L
Ref : Fundamental & Applied Toxicology , 1 :161 , 1981
PubMedID: 7184782