Amitai G

General

Full name : Amitai Gabriel

First name : Gabriel

Mail : Weizmann Institute of Science G-INCPM

Zip Code :

City :

Country : Israel

Email : amitai.gabi36@gmail.com

Phone : +97289381591

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References (45)

Title : Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase - Amitai_2021_Commun.Biol_4_573
Author(s) : Amitai G , Plotnikov A , Chapman S , Lazar S , Gez R , Loewenthal D , Shurrush KA , Cohen G , Solmesky LJ , Barr H , Russell AJ
Ref : Commun Biol , 4 :573 , 2021
PubMedID: 33990679

Title : Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer-Based Protein Engineering - Zhang_2020_Adv.Sci.(Weinh)_7_1901904
Author(s) : Zhang L , Baker SL , Murata H , Harris N , Ji W , Amitai G , Matyjaszewski K , Russell AJ
Ref : Adv Sci (Weinh) , 7 :1901904 , 2020
PubMedID: 31921563

Title : Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers - Zhang_2020_Biomacromolecules_21_3867
Author(s) : Zhang L , Murata H , Amitai G , Smith PN , Matyjaszewski K , Russell AJ
Ref : Biomacromolecules , 21 :3867 , 2020
PubMedID: 32786529

Title : Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity - Amitai_2016_Chem.Biol.Interact_259_187
Author(s) : Amitai G , Gez R , Raveh L , Bar-Ner N , Grauer E , Chapman S
Ref : Chemico-Biological Interactions , 259 :187 , 2016
PubMedID: 27129421

Title : Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification - Sit_2014_J.Med.Chem_57_1378
Author(s) : Sit RK , Fokin VV , Amitai G , Sharpless KB , Taylor P , Radic Z
Ref : Journal of Medicinal Chemistry , 57 :1378 , 2014
PubMedID: 24571195

Title : Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes - Radic_2013_Biochem.J_450_231
Author(s) : Radic Z , Dale T , Kovarik Z , Zunec S , Garcia E , Zhang LM , Amitai G , Green C , Radic B , Duggan BM , Ajami D , Rebek J , Taylor P
Ref : Biochemical Journal , 450 :231 , 2013
PubMedID: 23216060

Title : Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates - Radic_2013_Chem.Biol.Interact_203_67
Author(s) : Radic Z , Sit RK , Garcia E , Zhang LM , Zunec S , Kovarik Z , Amitai G , Fokin VV , Sharpless KB , Taylor P
Ref : Chemico-Biological Interactions , 203 :67 , 2013
PubMedID: 22975155

Title : Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases - Radic_2012_J.Biol.Chem_287_11798
Author(s) : Radic Z , Sit RK , Kovarik Z , Zunec S , Garcia E , Zhang L , Amitai G , Green C , Radic B , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 287 :11798 , 2012
PubMedID: 22343626

Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422
Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 286 :19422 , 2011
PubMedID: 21464125

Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718
Author(s) : Cochran R , Kalisiak J , Kucukkilinc TT , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P
Ref : Journal of Biological Chemistry , 286 :29718 , 2011
PubMedID: 21730071

Title : Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation - Kucukkilinc_2010_Chem.Biol.Interact_187_238
Author(s) : Kucukkilinc TT , Cochran R , Kalisiak J , Garcia E , Valle A , Amitai G , Radic Z , Taylor P
Ref : Chemico-Biological Interactions , 187 :238 , 2010
PubMedID: 20382137

Title : Decontamination of chemical and biological warfare agents with a single multi-functional material - Amitai_2010_Biomaterials_31_4417
Author(s) : Amitai G , Murata H , Andersen JD , Koepsel RR , Russell AJ
Ref : Biomaterials , 31 :4417 , 2010
PubMedID: 20199807

Title : Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity - Amitai_2008_Chem.Biol.Interact_175_249
Author(s) : Amitai G , Adani R , Limanovich O , Teitlboim S , Yishay S , Tveria L , Yacov G , Meshulam H , Raveh L
Ref : Chemico-Biological Interactions , 175 :249 , 2008
PubMedID: 18588863

Title : IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity - Nizri_2007_Int.Immunopharmacol_7_1129
Author(s) : Nizri E , Irony-Tur-Sinai M , Lavon I , Meshulam H , Amitai G , Brenner T
Ref : Int Immunopharmacol , 7 :1129 , 2007
PubMedID: 17630191

Title : Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity - Amitai_2007_Toxicology_233_187
Author(s) : Amitai G , Adani R , Yacov G , Yishay S , Teitlboim S , Tveria L , Limanovich O , Kushnir M , Meshulam H
Ref : Toxicology , 233 :187 , 2007
PubMedID: 17129656

Title : Directed evolution by in vitro compartmentalization -
Author(s) : Miller OJ , Bernath K , Agresti JJ , Amitai G , Kelly BT , Mastrobattista E , Taly V , Magdassi S , Tawfik DS , Griffiths AD
Ref : Nat Methods , 3 :561 , 2006
PubMedID: 16791215

Title : Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning - Lundy_2006_Toxicol.Rev_25_231
Author(s) : Lundy PM , Raveh L , Amitai G
Ref : Toxicol Rev , 25 :231 , 2006
PubMedID: 17288495

Title : Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase - Amitai_2006_FEBS.J_273_1906
Author(s) : Amitai G , Gaidukov L , Adani R , Yishay S , Yacov G , Kushnir M , Teitlboim S , Lindenbaum M , Bel P , Khersonsky O , Tawfik DS , Meshulam H
Ref : Febs J , 273 :1906 , 2006
PubMedID: 16640555

Title : Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning - Amitai_2006_J.Appl.Toxicol_26_81
Author(s) : Amitai G , Adani R , Fishbein E , Meshulam H , Laish I , Dachir S
Ref : J Appl Toxicol , 26 :81 , 2006
PubMedID: 16167317

Title : The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components - Farias_2005_Neurobiol.Dis_18_176
Author(s) : Farias GG , Godoy JA , Vazquez MC , Adani R , Meshulam H , Avila J , Amitai G , Inestrosa NC
Ref : Neurobiol Dis , 18 :176 , 2005
PubMedID: 15649708

Title : High-throughput screening of enzyme libraries: thiolactonases evolved by fluorescence-activated sorting of single cells in emulsion compartments - Aharoni_2005_Chem.Biol_12_1281
Author(s) : Aharoni A , Amitai G , Bernath K , Magdassi S , Tawfik DS
Ref : Chemical Biology , 12 :1281 , 2005
PubMedID: 16356845

Title : Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments - Nizri_2005_Neurosci.Lett_376_46
Author(s) : Nizri E , Adani R , Meshulam H , Amitai G , Brenner T
Ref : Neuroscience Letters , 376 :46 , 2005
PubMedID: 15694272

Title : Muscarinic modulations of neuronal anticholinesterase responses - Salmon_2005_Chem.Biol.Interact_157-158_105
Author(s) : Salmon A , Erb C , Meshorer E , Ginzberg D , Adani Y , Rabinovitz I , Amitai G , Soreq H
Ref : Chemico-Biological Interactions , 157-158 :105 , 2005
PubMedID: 16289123

Title : Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for CNS disorders. -
Author(s) : Amitai G , Adani R , Rabinovitz I , Beit-Yanai E , Shohami E , Sod-Moriah G , Meshulam H
Ref : Cholinergic Mechanisms, CRC Press :277 , 2004
PubMedID:

Title : Poster (56) The bifunctional compound IBU-PO elicits prolonged anti-inflammatory and cholinesterase inhibition in vivo -
Author(s) : Amitai G , Adani R , Rabinovitz I , Shohami E , Sod-Moriah G , Meshulam H
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :350 , 2004
PubMedID:

Title : Poster (64) Chloroperoxidases catalyzes the degradation of VX and sulfur mustard. -
Author(s) : Amitai G , Adani R , Hershkovitz M , Bel P , Rabinovitz I , Meshulam H
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :354 , 2004
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Title : Poster (80) The anti-inflammatory-cholinergic bifunctional compound ibu-po protects at sub-micromolar levels rat hippocampal cells from a beta-induced apoptosis and beta-catenin depletion -
Author(s) : Godoy JA , Adani R , Meshulam H , Inestrosa NC , Amitai G
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :363 , 2004
PubMedID:

Title : The anti-inflammatory bifunctional compound IBU-PO protects rat hippocampal neurons from A-beta-induced cytotoxicity and beta-catenin depletion -
Author(s) : Godoy JA , Adani R , Meshulam H , Inestrosa NC , Amitai G
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :135 , 2004
PubMedID:

Title : Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig - Gilat_2003_Arch.Toxicol_77_167
Author(s) : Gilat E , Goldman M , Lahat E , Levy A , Rabinovitz I , Cohen G , Brandeis R , Amitai G , Alkalai D , Eshel G
Ref : Archives of Toxicology , 77 :167 , 2003
PubMedID: 12632257

Title : Determination of therapeutic doses of bisquaternary oximes in large animals - Chen_2001_J.Appl.Toxicol_21_285
Author(s) : Chen R , Raveh L , Zomber G , Rabinovitz I , Cohen G , Adani R , Amitai G
Ref : J Appl Toxicol , 21 :285 , 2001
PubMedID: 11481661

Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195
Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y
Ref : FEBS Letters , 438 :195 , 1998
PubMedID: 9827544

Title : Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon - Amitai_1998_Biochem.Pharmacol_56_293
Author(s) : Amitai G , Moorad DR , Adani R , Doctor BP
Ref : Biochemical Pharmacology , 56 :293 , 1998
PubMedID: 9744565

Title : Quaternary-Lipophilic Carbamates with Blood Brain Barrier Permeability as Potential Drugs for the Treatment of Diseases Associated with Cholinergic Deficiency -
Author(s) : Amitai G , Adani R , Rabinovitz I , Sod-Moriah G , Brandeis R , Rachaman E , Heldman E
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :277 , 1998
PubMedID:

Title : Bisquaternary Oximes as Antidotes against Tabun and Soman Poisoning -
Author(s) : Amitai G , Rabinovitz I , Zomber G , Chen R , Cohen G , Adani R , Raveh L
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :345 , 1995
PubMedID:

Title : Poster: Characterization of peripheral anionic site peptides of AChE by photoaffinity labeling with monoazidopropidium (MAP) -
Author(s) : Amitai G , Taylor P
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :285 , 1991
PubMedID:

Title : Interaction of an organophosphate with a peripheral site on acetylcholinesterase - Friboulet_1990_Biochemistry_29_914
Author(s) : Friboulet A , Rieger F , Goudou D , Amitai G , Taylor P
Ref : Biochemistry , 29 :914 , 1990
PubMedID: 2340283

Title : The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor - Amitai_1987_Mol.Pharmacol_32_678
Author(s) : Amitai G , Herz JM , Bruckstein R , Luz-Chapman S
Ref : Molecular Pharmacology , 32 :678 , 1987
PubMedID: 3683366

Title : The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium - Amitai_1984_J.Biol.Chem_259_12519
Author(s) : Amitai G , Brown RD , Taylor P
Ref : Journal of Biological Chemistry , 259 :12519 , 1984
PubMedID: 6092338

Title : Molecular aspects of the biosynthesis and disposition of multiple forms of acetylcholinesterase -
Author(s) : Taylor P , Camp S , Lee SL , Amitai G , Taylor SS , Doctor BP
Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :145 , 1984
PubMedID:

Title : Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states - Avissar_1983_Proc.Natl.Acad.Sci.U.S.A_80_156
Author(s) : Avissar S , Amitai G , Sokolovsky M
Ref : Proc Natl Acad Sci U S A , 80 :156 , 1983
PubMedID: 6571990

Title : Affinity labeling of muscarinic receptors in rat cerebral cortex with a photolabile antagonist - Amitai_1982_Proc.Natl.Acad.Sci.U.S.A_79_243
Author(s) : Amitai G , Avissar S , Balderman D , Sokolovsky M
Ref : Proc Natl Acad Sci U S A , 79 :243 , 1982
PubMedID: 6952181

Title : Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase -
Author(s) : Amitai G , Ashani Y , Gafni A , Silman I
Ref : Biochemistry , 21 :2060 , 1982
PubMedID: 7093230

Title : New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase - Amitai_1980_Neurochem.Int_2C_199
Author(s) : Amitai G , Ashani Y , Gafni A , Silman I
Ref : Neurochem Int , 2C :199 , 1980
PubMedID: 20487784

Title : The interaction of bis-pyridinium oximes with mouse brain muscarinic receptor -
Author(s) : Amitai G , Kloog Y , Balderman D , Sokolovsky M
Ref : Biochemical Pharmacology , 29 :483 , 1980
PubMedID: 7370045

Title : Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue - Amitai_1980_Monogr.Neural.Sci_7_70
Author(s) : Amitai G , Ashani Y , Shahar A , Gafni A , Silman I
Ref : Monographs in Neural Sciences , 7 :70 , 1980
PubMedID: 7015117