Full name : Amitai Gabriel
First name : Gabriel
Mail : Weizmann Institute of Science G-INCPM
Zip Code :
City :
Country : Israel
Email : amitai.gabi36@gmail.com
Phone : +97289381591
Fax :
Website :
Directory :
Comment
| Title : Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase - Amitai_2021_Commun.Biol_4_573 |
| Author(s) : Amitai G , Plotnikov A , Chapman S , Lazar S , Gez R , Loewenthal D , Shurrush KA , Cohen G , Solmesky LJ , Barr H , Russell AJ |
| Ref : Commun Biol , 4 :573 , 2021 |
| Abstract : |
| PubMedSearch : Amitai_2021_Commun.Biol_4_573 |
| PubMedID: 33990679 |
| Title : Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer-Based Protein Engineering - Zhang_2020_Adv.Sci.(Weinh)_7_1901904 |
| Author(s) : Zhang L , Baker SL , Murata H , Harris N , Ji W , Amitai G , Matyjaszewski K , Russell AJ |
| Ref : Adv Sci (Weinh) , 7 :1901904 , 2020 |
| Abstract : |
| PubMedSearch : Zhang_2020_Adv.Sci.(Weinh)_7_1901904 |
| PubMedID: 31921563 |
| Title : Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers - Zhang_2020_Biomacromolecules_21_3867 |
| Author(s) : Zhang L , Murata H , Amitai G , Smith PN , Matyjaszewski K , Russell AJ |
| Ref : Biomacromolecules , 21 :3867 , 2020 |
| Abstract : |
| PubMedSearch : Zhang_2020_Biomacromolecules_21_3867 |
| PubMedID: 32786529 |
| Title : Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity - Amitai_2016_Chem.Biol.Interact_259_187 |
| Author(s) : Amitai G , Gez R , Raveh L , Bar-Ner N , Grauer E , Chapman S |
| Ref : Chemico-Biological Interactions , 259 :187 , 2016 |
| Abstract : |
| PubMedSearch : Amitai_2016_Chem.Biol.Interact_259_187 |
| PubMedID: 27129421 |
| Title : Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification - Sit_2014_J.Med.Chem_57_1378 |
| Author(s) : Sit RK , Fokin VV , Amitai G , Sharpless KB , Taylor P , Radic Z |
| Ref : Journal of Medicinal Chemistry , 57 :1378 , 2014 |
| Abstract : |
| PubMedSearch : Sit_2014_J.Med.Chem_57_1378 |
| PubMedID: 24571195 |
| Title : Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes - Radic_2013_Biochem.J_450_231 |
| Author(s) : Radic Z , Dale T , Kovarik Z , Zunec S , Garcia E , Zhang LM , Amitai G , Green C , Radic B , Duggan BM , Ajami D , Rebek J , Taylor P |
| Ref : Biochemical Journal , 450 :231 , 2013 |
| Abstract : |
| PubMedSearch : Radic_2013_Biochem.J_450_231 |
| PubMedID: 23216060 |
| Title : Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates - Radic_2013_Chem.Biol.Interact_203_67 |
| Author(s) : Radic Z , Sit RK , Garcia E , Zhang LM , Zunec S , Kovarik Z , Amitai G , Fokin VV , Sharpless KB , Taylor P |
| Ref : Chemico-Biological Interactions , 203 :67 , 2013 |
| Abstract : |
| PubMedSearch : Radic_2013_Chem.Biol.Interact_203_67 |
| PubMedID: 22975155 |
| Title : Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases - Radic_2012_J.Biol.Chem_287_11798 |
| Author(s) : Radic Z , Sit RK , Kovarik Z , Zunec S , Garcia E , Zhang L , Amitai G , Green C , Radic B , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 287 :11798 , 2012 |
| Abstract : |
| PubMedSearch : Radic_2012_J.Biol.Chem_287_11798 |
| PubMedID: 22343626 |
| Title : New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases - Sit_2011_J.Biol.Chem_286_19422 |
| Author(s) : Sit RK , Radic Z , Gerardi V , Zhang L , Garcia E , Katalinic M , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :19422 , 2011 |
| Abstract : |
| PubMedSearch : Sit_2011_J.Biol.Chem_286_19422 |
| PubMedID: 21464125 |
| Title : Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging - Cochran_2011_J.Biol.Chem_286_29718 |
| Author(s) : Cochran R , Kalisiak J , Tuylu Kucukkilinc T , Radic Z , Garcia E , Zhang L , Ho KY , Amitai G , Kovarik Z , Fokin VV , Sharpless KB , Taylor P |
| Ref : Journal of Biological Chemistry , 286 :29718 , 2011 |
| Abstract : |
| PubMedSearch : Cochran_2011_J.Biol.Chem_286_29718 |
| PubMedID: 21730071 |
| Title : Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation - Kucukkilinc_2010_Chem.Biol.Interact_187_238 |
| Author(s) : Tuylu Kucukkilinc T , Cochran R , Kalisiak J , Garcia E , Valle A , Amitai G , Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 187 :238 , 2010 |
| Abstract : |
| PubMedSearch : Kucukkilinc_2010_Chem.Biol.Interact_187_238 |
| PubMedID: 20382137 |
| Title : Decontamination of chemical and biological warfare agents with a single multi-functional material - Amitai_2010_Biomaterials_31_4417 |
| Author(s) : Amitai G , Murata H , Andersen JD , Koepsel RR , Russell AJ |
| Ref : Biomaterials , 31 :4417 , 2010 |
| Abstract : |
| PubMedSearch : Amitai_2010_Biomaterials_31_4417 |
| PubMedID: 20199807 |
| Title : Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity - Amitai_2008_Chem.Biol.Interact_175_249 |
| Author(s) : Amitai G , Adani R , Limanovich O , Teitlboim S , Yishay S , Tveria L , Yacov G , Meshulam H , Raveh L |
| Ref : Chemico-Biological Interactions , 175 :249 , 2008 |
| Abstract : |
| PubMedSearch : Amitai_2008_Chem.Biol.Interact_175_249 |
| PubMedID: 18588863 |
| Title : Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity - Amitai_2007_Toxicology_233_187 |
| Author(s) : Amitai G , Adani R , Yacov G , Yishay S , Teitlboim S , Tveria L , Limanovich O , Kushnir M , Meshulam H |
| Ref : Toxicology , 233 :187 , 2007 |
| Abstract : |
| PubMedSearch : Amitai_2007_Toxicology_233_187 |
| PubMedID: 17129656 |
| Title : IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity - Nizri_2007_Int.Immunopharmacol_7_1129 |
| Author(s) : Nizri E , Irony-Tur-Sinai M , Lavon I , Meshulam H , Amitai G , Brenner T |
| Ref : Int Immunopharmacol , 7 :1129 , 2007 |
| Abstract : |
| PubMedSearch : Nizri_2007_Int.Immunopharmacol_7_1129 |
| PubMedID: 17630191 |
| Title : Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase - Amitai_2006_FEBS.J_273_1906 |
| Author(s) : Amitai G , Gaidukov L , Adani R , Yishay S , Yacov G , Kushnir M , Teitlboim S , Lindenbaum M , Bel P , Khersonsky O , Tawfik DS , Meshulam H |
| Ref : Febs J , 273 :1906 , 2006 |
| Abstract : |
| PubMedSearch : Amitai_2006_FEBS.J_273_1906 |
| PubMedID: 16640555 |
| Title : Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning - Lundy_2006_Toxicol.Rev_25_231 |
| Author(s) : Lundy PM , Raveh L , Amitai G |
| Ref : Toxicol Rev , 25 :231 , 2006 |
| Abstract : |
| PubMedSearch : Lundy_2006_Toxicol.Rev_25_231 |
| PubMedID: 17288495 |
| Title : Directed evolution by in vitro compartmentalization - |
| Author(s) : Miller OJ , Bernath K , Agresti JJ , Amitai G , Kelly BT , Mastrobattista E , Taly V , Magdassi S , Tawfik DS , Griffiths AD |
| Ref : Nat Methods , 3 :561 , 2006 |
| PubMedID: 16791215 |
| Title : Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning - Amitai_2006_J.Appl.Toxicol_26_81 |
| Author(s) : Amitai G , Adani R , Fishbein E , Meshulam H , Laish I , Dachir S |
| Ref : J Appl Toxicol , 26 :81 , 2006 |
| Abstract : |
| PubMedSearch : Amitai_2006_J.Appl.Toxicol_26_81 |
| PubMedID: 16167317 |
| Title : Muscarinic modulations of neuronal anticholinesterase responses - Salmon_2005_Chem.Biol.Interact_157-158_105 |
| Author(s) : Salmon A , Erb C , Meshorer E , Ginzberg D , Adani Y , Rabinovitz I , Amitai G , Soreq H |
| Ref : Chemico-Biological Interactions , 157-158 :105 , 2005 |
| Abstract : |
| PubMedSearch : Salmon_2005_Chem.Biol.Interact_157-158_105 |
| PubMedID: 16289123 |
| Title : The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components - Farias_2005_Neurobiol.Dis_18_176 |
| Author(s) : Farias GG , Godoy JA , Vazquez MC , Adani R , Meshulam H , Avila J , Amitai G , Inestrosa NC |
| Ref : Neurobiol Dis , 18 :176 , 2005 |
| Abstract : |
| PubMedSearch : Farias_2005_Neurobiol.Dis_18_176 |
| PubMedID: 15649708 |
| Title : Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments - Nizri_2005_Neurosci.Lett_376_46 |
| Author(s) : Nizri E , Adani R , Meshulam H , Amitai G , Brenner T |
| Ref : Neuroscience Letters , 376 :46 , 2005 |
| Abstract : |
| PubMedSearch : Nizri_2005_Neurosci.Lett_376_46 |
| PubMedID: 15694272 |
| Title : High-throughput screening of enzyme libraries: thiolactonases evolved by fluorescence-activated sorting of single cells in emulsion compartments - Aharoni_2005_Chem.Biol_12_1281 |
| Author(s) : Aharoni A , Amitai G , Bernath K , Magdassi S , Tawfik DS |
| Ref : Chemical Biology , 12 :1281 , 2005 |
| Abstract : |
| PubMedSearch : Aharoni_2005_Chem.Biol_12_1281 |
| PubMedID: 16356845 |
| Title : The anti-inflammatory bifunctional compound IBU-PO protects rat hippocampal neurons from A-beta-induced cytotoxicity and beta-catenin depletion - |
| Author(s) : Godoy JA , Adani R , Meshulam H , Inestrosa NC , Amitai G |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :135 , 2004 |
| PubMedID: |
| Title : Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for CNS disorders. - |
| Author(s) : Amitai G , Adani R , Rabinovitz I , Beit-Yanai E , Shohami E , Sod-Moriah G , Meshulam H |
| Ref : Cholinergic Mechanisms, CRC Press :277 , 2004 |
| PubMedID: |
| Title : Poster (56) The bifunctional compound IBU-PO elicits prolonged anti-inflammatory and cholinesterase inhibition in vivo - |
| Author(s) : Amitai G , Adani R , Rabinovitz I , Shohami E , Sod-Moriah G , Meshulam H |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :350 , 2004 |
| PubMedID: |
| Title : Poster (64) Chloroperoxidases catalyzes the degradation of VX and sulfur mustard. - |
| Author(s) : Amitai G , Adani R , Hershkovitz M , Bel P , Rabinovitz I , Meshulam H |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :354 , 2004 |
| PubMedID: |
| Title : Poster (80) The anti-inflammatory-cholinergic bifunctional compound ibu-po protects at sub-micromolar levels rat hippocampal cells from a beta-induced apoptosis and beta-catenin depletion - |
| Author(s) : Godoy JA , Adani R , Meshulam H , Inestrosa NC , Amitai G |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :363 , 2004 |
| PubMedID: |
| Title : Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig - Gilat_2003_Arch.Toxicol_77_167 |
| Author(s) : Gilat E , Goldman M , Lahat E , Levy A , Rabinovitz I , Cohen G , Brandeis R , Amitai G , Alkalai D , Eshel G |
| Ref : Archives of Toxicology , 77 :167 , 2003 |
| Abstract : |
| PubMedSearch : Gilat_2003_Arch.Toxicol_77_167 |
| PubMedID: 12632257 |
| Title : Determination of therapeutic doses of bisquaternary oximes in large animals - Chen_2001_J.Appl.Toxicol_21_285 |
| Author(s) : Chen R , Raveh L , Zomber G , Rabinovitz I , Cohen G , Adani R , Amitai G |
| Ref : J Appl Toxicol , 21 :285 , 2001 |
| Abstract : |
| PubMedSearch : Chen_2001_J.Appl.Toxicol_21_285 |
| PubMedID: 11481661 |
| Title : Quaternary-Lipophilic Carbamates with Blood Brain Barrier Permeability as Potential Drugs for the Treatment of Diseases Associated with Cholinergic Deficiency - |
| Author(s) : Amitai G , Adani R , Rabinovitz I , Sod-Moriah G , Brandeis R , Rachaman E , Heldman E |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :277 , 1998 |
| PubMedID: |
| Title : Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon - Amitai_1998_Biochem.Pharmacol_56_293 |
| Author(s) : Amitai G , Moorad DR , Adani R , Doctor BP |
| Ref : Biochemical Pharmacology , 56 :293 , 1998 |
| Abstract : |
| PubMedSearch : Amitai_1998_Biochem.Pharmacol_56_293 |
| PubMedID: 9744565 |
| Title : Oxidative biodegradation of phosphorothiolates by fungal laccase - Amitai_1998_FEBS.Lett_438_195 |
| Author(s) : Amitai G , Adani R , Sod-Moriah G , Rabinovitz I , Vincze A , Leader H , Chefetz B , Leibovitz-Persky L , Friesem D , Hadar Y |
| Ref : FEBS Letters , 438 :195 , 1998 |
| Abstract : |
| PubMedSearch : Amitai_1998_FEBS.Lett_438_195 |
| PubMedID: 9827544 |
| Title : Bisquaternary Oximes as Antidotes against Tabun and Soman Poisoning - |
| Author(s) : Amitai G , Rabinovitz I , Zomber G , Chen R , Cohen G , Adani R , Raveh L |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :345 , 1995 |
| PubMedID: |
| Title : Poster: Characterization of peripheral anionic site peptides of AChE by photoaffinity labeling with monoazidopropidium (MAP) - |
| Author(s) : Amitai G , Taylor P |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :285 , 1991 |
| PubMedID: |
| Title : Interaction of an organophosphate with a peripheral site on acetylcholinesterase - Friboulet_1990_Biochemistry_29_914 |
| Author(s) : Friboulet A , Rieger F , Goudou D , Amitai G , Taylor P |
| Ref : Biochemistry , 29 :914 , 1990 |
| Abstract : |
| PubMedSearch : Friboulet_1990_Biochemistry_29_914 |
| PubMedID: 2340283 |
| Title : The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor - Amitai_1987_Mol.Pharmacol_32_678 |
| Author(s) : Amitai G , Herz JM , Bruckstein R , Luz-Chapman S |
| Ref : Molecular Pharmacology , 32 :678 , 1987 |
| Abstract : |
| PubMedSearch : Amitai_1987_Mol.Pharmacol_32_678 |
| PubMedID: 3683366 |
| Title : Molecular aspects of the biosynthesis and disposition of multiple forms of acetylcholinesterase - |
| Author(s) : Taylor P , Camp S , Lee SL , Amitai G , Taylor SS , Doctor BP |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :145 , 1984 |
| PubMedID: |
| Title : The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium - Amitai_1984_J.Biol.Chem_259_12519 |
| Author(s) : Amitai G , Brown RD , Taylor P |
| Ref : Journal of Biological Chemistry , 259 :12519 , 1984 |
| Abstract : |
| PubMedSearch : Amitai_1984_J.Biol.Chem_259_12519 |
| PubMedID: 6092338 |
| Title : Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states - Avissar_1983_Proc.Natl.Acad.Sci.U.S.A_80_156 |
| Author(s) : Avissar S , Amitai G , Sokolovsky M |
| Ref : Proc Natl Acad Sci U S A , 80 :156 , 1983 |
| Abstract : |
| PubMedSearch : Avissar_1983_Proc.Natl.Acad.Sci.U.S.A_80_156 |
| PubMedID: 6571990 |
| Title : Affinity labeling of muscarinic receptors in rat cerebral cortex with a photolabile antagonist - Amitai_1982_Proc.Natl.Acad.Sci.U.S.A_79_243 |
| Author(s) : Amitai G , Avissar S , Balderman D , Sokolovsky M |
| Ref : Proc Natl Acad Sci U S A , 79 :243 , 1982 |
| Abstract : |
| PubMedSearch : Amitai_1982_Proc.Natl.Acad.Sci.U.S.A_79_243 |
| PubMedID: 6952181 |
| Title : New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase - Amitai_1980_Neurochem.Int_2C_199 |
| Author(s) : Amitai G , Ashani Y , Gafni A , Silman I |
| Ref : Neurochem Int , 2C :199 , 1980 |
| Abstract : |
| PubMedSearch : Amitai_1980_Neurochem.Int_2C_199 |
| PubMedID: 20487784 |
| Title : The interaction of bis-pyridinium oximes with mouse brain muscarinic receptor - |
| Author(s) : Amitai G , Kloog Y , Balderman D , Sokolovsky M |
| Ref : Biochemical Pharmacology , 29 :483 , 1980 |
| PubMedID: 7370045 |
| Title : Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue - Amitai_1980_Monogr.Neural.Sci_7_70 |
| Author(s) : Amitai G , Ashani Y , Shahar A , Gafni A , Silman I |
| Ref : Monographs in Neural Sciences , 7 :70 , 1980 |
| Abstract : |
| PubMedSearch : Amitai_1980_Monogr.Neural.Sci_7_70 |
| PubMedID: 7015117 |