Szinicz L

General

Full name : Szinicz Ladislaus

First name : Ladislaus

Mail : Institute of Pharmacology & Toxicology, FAF Medical Academy, D-85748 Garching

Zip Code :

City :

Country : Germany

Email :

Phone : 49-89-315-5063

Fax : 49-89-375-5063

Website :

Directory :

References (51)

Title : Obituary: In memory of Elsa Reiner - Eyer_2011_Toxicol.Lett_206_1
Author(s) : Eyer P , Szinicz L
Ref : Toxicol Lett , 206 :1 , 2011
PubMedID:

Title : Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning - Thiermann_2007_Toxicology_233_145
Author(s) : Thiermann H , Szinicz L , Eyer P , Felgenhauer N , Zilker T , Worek F
Ref : Toxicology , 233 :145 , 2007
PubMedID: 17161895

Title : Apoptosis in sulfur mustard treated A549 cell cultures - Steinritz_2007_Life.Sci_80_2199
Author(s) : Steinritz D , Emmler J , Hintz M , Worek F , Kreppel H , Szinicz L , Kehe K
Ref : Life Sciences , 80 :2199 , 2007
PubMedID: 17229443

Title : Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis - Worek_2007_Toxicol.Appl.Pharmacol_219_226
Author(s) : Worek F , Eyer P , Aurbek N , Szinicz L , Thiermann H
Ref : Toxicol Appl Pharmacol , 219 :226 , 2007
PubMedID: 17112559

Title : Simulation of cholinesterase status at different scenarios of nerve agent exposure - Worek_2007_Toxicology_233_155
Author(s) : Worek F , Eyer P , Szinicz L , Thiermann H
Ref : Toxicology , 233 :155 , 2007
PubMedID: 16904807

Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166
Author(s) : Bartling A , Worek F , Szinicz L , Thiermann H
Ref : Toxicology , 233 :166 , 2007
PubMedID: 16904809

Title : Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro - Becker_2007_Arch.Toxicol_81_415
Author(s) : Becker G , Kawan A , Gutzeit D , Worek F , Szinicz L
Ref : Archives of Toxicology , 81 :415 , 2007
PubMedID: 17151865

Title : Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality - Eyer_2007_Toxicology_233_108
Author(s) : Eyer P , Szinicz L , Thiermann H , Worek F , Zilker T
Ref : Toxicology , 233 :108 , 2007
PubMedID: 17010492

Title : Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro - Seeger_2007_Toxicology_233_209
Author(s) : Seeger T , Worek F , Szinicz L , Thiermann H
Ref : Toxicology , 233 :209 , 2007
PubMedID: 17250944

Title : Development of antidotes: problems and strategies - Szinicz_2007_Toxicology_233_23
Author(s) : Szinicz L , Worek F , Thiermann H , Kehe K , Eckert S , Eyer P
Ref : Toxicology , 233 :23 , 2007
PubMedID: 16949190

Title : Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase - Aurbek_2006_Toxicology_224_91
Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F
Ref : Toxicology , 224 :91 , 2006
PubMedID: 16720069

Title : Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning - Aurbek_2006_Toxicology_224_74
Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F
Ref : Toxicology , 224 :74 , 2006
PubMedID: 16740352

Title : Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon - Thiermann_2005_Toxicology_214_190
Author(s) : Thiermann H , Eyer P , Worek F , Szinicz L
Ref : Toxicology , 214 :190 , 2005
PubMedID: 16040183

Title : Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning - Thiermann_2005_Chem.Biol.Interact_157-158_345
Author(s) : Thiermann H , Szinicz L , Eyer P , Zilker T , Worek F
Ref : Chemico-Biological Interactions , 157-158 :345 , 2005
PubMedID: 16263103

Title : Diagnostic aspects of organophosphate poisoning - Worek_2005_Toxicology_214_182
Author(s) : Worek F , Koller M , Thiermann H , Szinicz L
Ref : Toxicology , 214 :182 , 2005
PubMedID: 16051411

Title : Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model - Worek_2005_Toxicol.Appl.Pharmacol_209_193
Author(s) : Worek F , Szinicz L , Eyer P , Thiermann H
Ref : Toxicol Appl Pharmacol , 209 :193 , 2005
PubMedID: 15904945

Title : Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study - Eddleston_2005_Lancet_366_1452
Author(s) : Eddleston M , Eyer P , Worek F , Mohamed F , Senarathna L , von Meyer L , Juszczak E , Hittarage A , Azhar S , Dissanayake W , Sheriff MH , Szinicz L , Dawson AH , Buckley NA
Ref : Lancet , 366 :1452 , 2005
PubMedID: 16243090

Title : Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach - Worek_2005_Chem.Biol.Interact_157-158_349
Author(s) : Worek F , Szinicz L , Thiermann H
Ref : Chemico-Biological Interactions , 157-158 :349 , 2005
PubMedID: 16266695

Title : Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro - Bartling_2005_J.Appl.Toxicol_25_568
Author(s) : Bartling A , Thiermann H , Szinicz L , Worek F
Ref : J Appl Toxicol , 25 :568 , 2005
PubMedID: 16167316

Title : Oximes for acute organophosphate pesticide poisoning - Buckley_2005_Cochrane.Database.Syst.Rev__CD005085
Author(s) : Buckley NA , Eddleston M , Szinicz L
Ref : Cochrane Database Syst Rev , :CD005085 , 2005
PubMedID: 15654704

Title : Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines - Worek_2004_Arch.Toxicol_78_212
Author(s) : Worek F , Thiermann H , Szinicz L
Ref : Archives of Toxicology , 78 :212 , 2004
PubMedID: 14647978

Title : Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes - Worek_2004_Biochem.Pharmacol_68_2237
Author(s) : Worek F , Thiermann H , Szinicz L , Eyer P
Ref : Biochemical Pharmacology , 68 :2237 , 2004
PubMedID: 15498514

Title : Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase - Herkenhoff_2004_Arch.Toxicol_78_338
Author(s) : Herkenhoff S , Szinicz L , Rastogi VK , Cheng TC , DeFrank JJ , Worek F
Ref : Archives of Toxicology , 78 :338 , 2004
PubMedID: 14985944

Title : The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices - Grasshoff_2003_Toxicology_184_149
Author(s) : Grasshoff C , Gillessen T , Thiermann H , Wagner E , Szinicz L
Ref : Toxicology , 184 :149 , 2003
PubMedID: 12499118

Title : Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates - Worek_2002_Arch.Toxicol_76_523
Author(s) : Worek F , Reiter G , Eyer P , Szinicz L
Ref : Archives of Toxicology , 76 :523 , 2002
PubMedID: 12242610

Title : Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials - Eddleston_2002_QJM_95_275
Author(s) : Eddleston M , Szinicz L , Eyer P , Buckley N
Ref : Qjm , 95 :275 , 2002
PubMedID: 11978898

Title : Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients - Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203
Author(s) : Grasshoff C , Thiermann H , Gillessen T , Zilker T , Szinicz L
Ref : Journal of Chromatography B Biomed Sci Appl , 753 :203 , 2001
PubMedID: 11334332

Title : Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase - Worek_2000_Arch.Toxicol_74_21
Author(s) : Worek F , Eyer P , Kiderlen D , Thiermann H , Szinicz L
Ref : Archives of Toxicology , 74 :21 , 2000
PubMedID: 10817663

Title : Modern strategies in therapy of organophosphate poisoning - Thiermann_1999_Toxicol.Lett_107_233
Author(s) : Thiermann H , Szinicz L , Eyer F , Worek F , Eyer P , Felgenhauer N , Zilker T
Ref : Toxicol Lett , 107 :233 , 1999
PubMedID: 10414801

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
Author(s) : Worek F , Widmann R , Knopff O , Szinicz L
Ref : Archives of Toxicology , 72 :237 , 1998
PubMedID: 9587020

Title : Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases - Worek_1998_Arch.Toxicol_72_580
Author(s) : Worek F , Eyer P , Szinicz L
Ref : Archives of Toxicology , 72 :580 , 1998
PubMedID: 9806430

Title : Acetylcholinesterase, a Versatile Protein -
Author(s) : Szinicz L , Thiermann H , Worek F , Eyer P
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :269 , 1998
PubMedID:

Title : Direct reaction of oximes with sarin, soman, or tabun in vitro - Becker_1997_Arch.Toxicol_71_714
Author(s) : Becker G , Kawan A , Szinicz L
Ref : Archives of Toxicology , 71 :714 , 1997
PubMedID: 9363846

Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466
Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P
Ref : Hum Exp Toxicol , 16 :466 , 1997
PubMedID: 9292287

Title : Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds - Worek_1996_Arch.Toxicol_70_497
Author(s) : Worek F , Kirchner T , Backer M , Szinicz L
Ref : Archives of Toxicology , 70 :497 , 1996
PubMedID: 8783813

Title : Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment - Worek_1995_Arch.Toxicol_69_322
Author(s) : Worek F , Szinicz L
Ref : Archives of Toxicology , 69 :322 , 1995
PubMedID: 7654137

Title : Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning - Worek_1995_Human.Exp.Toxicol_14_634
Author(s) : Worek F , Kleine A , Szinicz L
Ref : Hum Exp Toxicol , 14 :634 , 1995
PubMedID: 7576830

Title : Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro - Hallek_1995_Arch.Toxicol_70_16
Author(s) : Hallek M , Szinicz L
Ref : Archives of Toxicology , 70 :16 , 1995
PubMedID: 8750900

Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Toxicology , 95 :123 , 1995
PubMedID: 7825179

Title : Effects of atropine and soman on the pharmacokinetics of the oxime HLo 7 dimethanesulfonate in anesthetized guinea-pigs - Worek_1995_Drug.Chem.Toxicol_18_137
Author(s) : Worek F , Klimmek R , Szinicz L
Ref : Drug & Chemical Toxicology , 18 :137 , 1995
PubMedID: 7497908

Title : Arrhythmias in organophosphate poisoning: effect of atropine and bispyridinium oximes - Worek_1995_Arch.Int.Pharmacodyn.Ther_329_418
Author(s) : Worek F , Kleine A , Falke K , Szinicz L
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 329 :418 , 1995
PubMedID: 8546540

Title : Treatment of tabun poisoned guinea-pigs with atropine, HLo 7 or HI 6: effect on respiratory and circulatory function - Worek_1994_Arch.Toxicol_68_231
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Archives of Toxicology , 68 :231 , 1994
PubMedID: 8067895

Title : Effect of atropine, HLo 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX) - Worek_1994_Pharmacol.Toxicol_75_302
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Pharmacol Toxicol , 75 :302 , 1994
PubMedID: 7870702

Title : A homogeneous immunological detection system for soman using the in vitro protection of acetylcholinesterase by a monoclonal antibody - Erhard_1993_Arch.Toxicol_67_220
Author(s) : Erhard MH , Jungling A , Schoneberg T , Szinicz L , Losch U
Ref : Archives of Toxicology , 67 :220 , 1993
PubMedID: 8494502

Title : Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLo 7 dimethanesulfonate versus HI 6 dichloride - Worek_1993_Pharmacol.Toxicol_72_13
Author(s) : Worek F , Szinicz L
Ref : Pharmacol Toxicol , 72 :13 , 1993
PubMedID: 8441735

Title : Investigation of acute cardiovascular and respiratory toxicity of HLo 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs - Worek_1993_Pharmacol.Toxicol_73_91
Author(s) : Worek F , Szinicz L
Ref : Pharmacol Toxicol , 73 :91 , 1993
PubMedID: 8248012

Title : HLo 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases - Eyer_1992_Arch.Toxicol_66_603
Author(s) : Eyer P , Hagedorn I , Klimmek R , Lippstreu P , Loffler M , Oldiges H , Spohrer U , Steidl I , Szinicz L , Worek F
Ref : Archives of Toxicology , 66 :603 , 1992
PubMedID: 1482283

Title : Detection of the organophosphorus nerve agent soman by an ELISA using monoclonal antibodies - Erhard_1990_Arch.Toxicol_64_580
Author(s) : Erhard MH , Kuhlmann R , Szinicz L , Losch U
Ref : Archives of Toxicology , 64 :580 , 1990
PubMedID: 2073131

Title : Effects of some mono- and bisquaternary ammonium compounds on the reactivatability of soman-inhibited human acetylcholinesterase in vitro - Hallek_1988_Biochem.Pharmacol_37_819
Author(s) : Hallek M , Szinicz L
Ref : Biochemical Pharmacology , 37 :819 , 1988
PubMedID: 3345199

Title : Studies on the role of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice - Reithmann_1988_Arch.Toxicol_62_41
Author(s) : Reithmann C , Arbogast H , Hallek M , Auburger G , Szinicz L
Ref : Archives of Toxicology , 62 :41 , 1988
PubMedID: 3190454

Title : Therapeutic effects of new oximes, benactyzine and atropine in Soman poisoning: Part I. Effects of various oximes in Soman, Sarin, and Vx poisoning in dogs -
Author(s) : Weger N , Szinicz L
Ref : Fundamental & Applied Toxicology , 1 :161 , 1981
PubMedID: 7184782