Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f
AChE and MAO-B enzyme with IC50 values of 23.4 +/- 1.1 nM and 40.3 +/- 1.7 nM, respectively
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Piperazine, Carboxamide, Benzothiazol, Sulfur Compound
Chemical_Nomenclature : N-(Benzo[d]thiazol-2-yl)-4-((4-(2-(dimethylamino)ethyl)piperazine-1-yl)methyl)benzamide
Canonical SMILES : C1=CC=C2C(=C1)SC(=N2)NC(C3=CC=C(C=C3)CN4CCN(CC4)CCN(C)C)=O
InChI : InChI=1S\/C23H29N5OS\/c1-26(2)11-12-27-13-15-28(16-14-27)17-18-7-9-19(10-8-18)22(29)25-23-24-20-5-3-4-6-21(20)30-23\/h3-10H,11-17H2,1-2H3,(H,24,25,29)
InChIKey : RYKFYEQANBUUEN-UHFFFAOYSA-N
Other name(s) : Compound 4f
Target
Families : Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ligand of proteins in family
ACHE
References (1)
| Title : Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease - Karaca_2022_RSC.Adv_12_23626 |
| Author(s) : Karaca S , Osmaniye D , Saglik BN , Levent S , Ilgin S , Ozkay Y , Karaburun A , Kaplancikli ZA , Gundogdu-Karaburun N |
| Ref : RSC Adv , 12 :23626 , 2022 |
| Abstract : |
| PubMedSearch : Karaca_2022_RSC.Adv_12_23626 |
| PubMedID: 36090440 |