Benzyl-bromophenyl-piperidine-carboxamide-Cpd8
eeAChE IC50 nM 93.09 +/- 8.41
General
Type : Derivative of Donepezil, Benzylpiperidine, Piperidine, Carboxamide
Chemical_Nomenclature : 1-Benzyl-N-(2-bromophenyl)piperidine-4-carboxamide
Canonical SMILES : C1CN(CCC1C(=O)NC2=CC=CC=C2Br)CC3=CC=CC=C3
InChI : InChI=1S\/C19H21BrN2O\/c20-17-8-4-5-9-18(17)21-19(23)16-10-12-22(13-11-16)14-15-6-2-1-3-7-15\/h1-9,16H,10-14H2,(H,21,23)
InChIKey : KLPRYRYZXQCDOY-UHFFFAOYSA-N
Other name(s) : Compound 8
MW : 373.3
Formula : C19H21BrN2O
CAS_number :
PubChem : 124338102
UniChem : KLPRYRYZXQCDOY-UHFFFAOYSA-N
Target
Families : Benzyl-bromophenyl-piperidine-carboxamide-Cpd8 ligand of proteins in family
ACHE
Protein :
eleel-ACHE
References (1)
| Title : Integrated computational and automated flow synthesis platform for the rapid discovery of N-benzylpiperidine acetylcholinesterase inhibitors - Reinhardt_2026_Eur.J.Med.Chem_319_119259 |
| Author(s) : Reinhardt AM , Theron A , Tantoh ALA , Malan FP , Panayides JL , Riley DL |
| Ref : Eur Journal of Medicinal Chemistry , 319 :119259 , 2026 |
| Abstract : |
| PubMedSearch : Reinhardt_2026_Eur.J.Med.Chem_319_119259 |
| PubMedID: 42691699 |