Benzyl-hydroxyphenyl-piperidine-carboxamide-Cpd12
eeAChE IC50 nM 117.43 +/- 7.11
General
Type : Derivative of Donepezil, Benzylpiperidine, Piperidine, Carboxamide
Chemical_Nomenclature : 1-Benzyl-N-(2-hydroxyphenyl)piperidine-4-carboxamide
Canonical SMILES : C1(=CC=CC=C1)CN2CCC(CC2)C(=O)NC3=C(C=CC=C3)O
InChI : InChI=1S\/C19H22N2O2\/c22-18-9-5-4-8-17(18)20-19(23)16-10-12-21(13-11-16)14-15-6-2-1-3-7-15\/h1-9,16,22H,10-14H2,(H,20,23)
InChIKey : NHRYMAOFGYHVNK-UHFFFAOYSA-N
Other name(s) : Compound 12
Target
Families : Benzyl-hydroxyphenyl-piperidine-carboxamide-Cpd12 ligand of proteins in family
ACHE
Protein :
eleel-ACHE
References (1)
| Title : Integrated computational and automated flow synthesis platform for the rapid discovery of N-benzylpiperidine acetylcholinesterase inhibitors - Reinhardt_2026_Eur.J.Med.Chem_319_119259 |
| Author(s) : Reinhardt AM , Theron A , Tantoh ALA , Malan FP , Panayides JL , Riley DL |
| Ref : Eur Journal of Medicinal Chemistry , 319 :119259 , 2026 |
| Abstract : |
| PubMedSearch : Reinhardt_2026_Eur.J.Med.Chem_319_119259 |
| PubMedID: 42691699 |