Benzyl-piperidine-4-ethyl-phthalimide-6c
IC50 13.2 nM
General
Type : Derivative of Donepezil
Chemical_Nomenclature : 2-(2-(1-benzylpiperidin-4-yl)ethyl)isoindoline-1,3-dione
Canonical SMILES : C1CN(CCC1CCN2C(=O)C3=CC=CC=C3C2=O)CC4=CC=CC=C4
InChI : InChI=1S\/C22H24N2O2\/c25-21-19-8-4-5-9-20(19)22(26)24(21)15-12-17-10-13-23(14-11-17)16-18-6-2-1-3-7-18\/h1-9,17H,10-16H2
InChIKey : CRPBEXXXEBUOEC-UHFFFAOYSA-N
Other name(s) : CHEMBL106891 || DTXSID20433952 || Compound 6c
MW :
Formula : C22H24N2O2
CAS_number : 113027-75-1
PubChem : 9997900
UniChem : CRPBEXXXEBUOEC-UHFFFAOYSA-N
Target
Families : Benzyl-piperidine-4-ethyl-phthalimide-6c ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Amine-containing donepezil analogues as potent acetylcholinesterase inhibitors with increased polarity - Kaltbeitzel_2024_RSC.Med.Chem_15_2037 |
| Author(s) : Kaltbeitzel J , Kersten C , Wich PR |
| Ref : RSC Med Chem , 15 :2037 , 2024 |
| Abstract : |
| PubMedSearch : Kaltbeitzel_2024_RSC.Med.Chem_15_2037 |
| PubMedID: 38911155 |
| Title : A comparison of methods for modeling quantitative structure-activity relationships - Sutherland_2004_J.Med.Chem_47_5541 |
| Author(s) : Sutherland JJ , O'Brien LA , Weaver DF |
| Ref : Journal of Medicinal Chemistry , 47 :5541 , 2004 |
| Abstract : |
| PubMedSearch : Sutherland_2004_J.Med.Chem_47_5541 |
| PubMedID: 15481990 |
| Title : Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives - Sugimoto_1992_J.Med.Chem_35_4542 |
| Author(s) : Sugimoto H , Tsuchiya Y , Sugumi H , Higurashi K , Karibe N , Iimura Y , Sasaki A , Araki S , Yamanishi Y , Yamatsu K |
| Ref : Journal of Medicinal Chemistry , 35 :4542 , 1992 |
| Abstract : |
| PubMedSearch : Sugimoto_1992_J.Med.Chem_35_4542 |
| PubMedID: 1469686 |