Biphenyl-oxo-triazine-S-12
AChE IC50 0.486 +/- 0.047 microM, BACE-1 IC50 0.542 +/- 0.099 microM), good anti-A aggregation effects in thioflavin-T assay
General
Type : Multitarget, Triazine
Chemical_Nomenclature : N-(3,5-dimethoxyphenyl)-2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3h)-yl)acetamide
Canonical SMILES : C1=CC=C(C=C1)C2=NN(C(N=C2C3=CC=CC=C3)=O)CC(=O)NC4=CC(=CC(=C4)OC)OC
InChI : InChI=1S\/C25H22N4O4\/c1-32-20-13-19(14-21(15-20)33-2)26-22(30)16-29-25(31)27-23(17-9-5-3-6-10-17)24(28-29)18-11-7-4-8-12-18\/h3-15H,16H2,1-2H3,(H,26,30)
InChIKey : CWGFQVMBODQAPR-UHFFFAOYSA-N
Other name(s) : Compound S-12
Target
References (1)
| Title : Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy - Waiker_2024_Eur.J.Med.Chem_271_116409 |
| Author(s) : Waiker DK , Verma A , Gajendra TA , Namrata , Roy A , Kumar P , Trigun SK , Srikrishna S , Krishnamurthy S , Davisson VJ , Shrivastava SK |
| Ref : Eur Journal of Medicinal Chemistry , 271 :116409 , 2024 |
| Abstract : |
| PubMedSearch : Waiker_2024_Eur.J.Med.Chem_271_116409 |
| PubMedID: 38663285 |