CHEMBL3343927
AChE IC50 0.0216 microM; BChE IC50 0.0398 microM; amyloid beta self-induced aggregation at 20 microM
General
Type : beta-carboline, Acridine, Derivative of Tacrine, Multitarget, Alkyl linked bis-ligand
Chemical_Nomenclature : (3S)-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCNC(=O)[C@@H]4CC5=C(CN4)NC6=CC=CC=C56
InChI : InChI=1S\/C31H37N5O\/c37-31(28-19-24-21-11-3-6-14-25(21)36-29(24)20-34-28)33-18-10-2-1-9-17-32-30-22-12-4-7-15-26(22)35-27-16-8-5-13-23(27)30\/h3-4,6-7,11-12,14-15,28,34,36H,1-2,5,8-10,13,16-20H2,(H,32,35)(H,33,37)\/t28-\/m0\/s1
InChIKey : LBOYVYBBAFDIGX-NDEPHWFRSA-N
Other name(s) : BDBM50099598
MW : 495.7
Formula : C31H37N5O
CAS_number :
PubChem : 87056148
UniChem : LBOYVYBBAFDIGX-NDEPHWFRSA-N
Target
References (2)
| Title : beta-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy - Beato_2021_J.Med.Chem__ |
| Author(s) : Beato A , Gori A , Boucherle B , Peuchmaur M , Haudecoeur R |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Beato_2021_J.Med.Chem__ |
| PubMedID: 33528252 |
| Title : Design, synthesis and evaluation of novel tacrine-(beta-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease - Lan_2014_Bioorg.Med.Chem_22_6089 |
| Author(s) : Lan JS , Xie SS , Li SY , Pan LF , Wang XB , Kong LY |
| Ref : Bioorganic & Medicinal Chemistry , 22 :6089 , 2014 |
| Abstract : |
| PubMedSearch : Lan_2014_Bioorg.Med.Chem_22_6089 |
| PubMedID: 25282654 |