Alkyl linked bis-ligand

General

Multitarget compound inhibitors of cholinesterase often bear an alkyl linker that span the active site gorge from the catalytic anionic site to the peripheral anionic site.
Inhibitor Main targeted enzyme families Type Structure
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-acridine-17d ACHE Multitarget Acridine Derivative of Tacrine Antioxidant tert-Butyl Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d BCHE Multitarget Derivative of Tacrine Quinoline Antioxidant tert-Butyl Alkyl linked bis-ligand
10c-Salicylimine-Tacrine BCHE Acridine Derivative of Tacrine Salicylic Alkyl linked bis-ligand
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
Melatonin-alkylbenzylamine-Cpd5 BCHE Antioxidant Derivative of Tryptamine Indole Multitarget Alkyl linked bis-ligand
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
Quinone-polyamine-NSAID-4 BCHE Multitarget 5-Lipoxygenase inhibitor Alkyl linked bis-ligand
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Hydroxycinnamic-ester Alkyl linked bis-ligand
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
Amantadine-M30D-hybrid5e BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Adamantyl Alkyl linked bis-ligand
Tacrine-pentylmethylene-tolylsulfonamide ACHE BCHE Alkyl linked bis-ligand Derivative of Tacrine Sulfur Compound Sulfonamide Benzenesulfonamide
Methoctramine Muscarinic antagonist Not A\/B H target Alkyl linked bis-ligand
Bivalent-4-Aminopyridine-12i ACHE Pyridine Alkyl linked bis-ligand
2-tolylazo-1,3-aminoenketone-tacrine-7a Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant
Salicylamide-8-Tacrine ACHE BCHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant Salicylic
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Tacrine-dipicolylamine-13a ACHE Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
8U2-7AIX7AY-compound5i ACHE BCHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8U5-7AIW-compound5g ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UE-7AIV-compound5f ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UQ-7AIU-compound5d ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UK-7AIT-compound5c ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UH-7AIS-compound5b ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
DTE-bis8-Tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine Photoswitch Sulfur Compound
Cpd14-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Indole Alkyl linked bis-ligand
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd54-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand tert-Butyloxycarbonyl tert-Butyl
Cpd70-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Indole Alkyl linked bis-ligand
Cpd27-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamate Monoglyceridelipase_lysophospholip Multitarget Carbamate Indole FAAH inhibitor Alkyl linked bis-ligand
Tacrine-methylanacardate-cpd5 BCHE Multitarget Derivative of Tacrine Salicylic Alkyl linked bis-ligand Benzoate
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
N-alkyl-quinuclidine-cpd14 BCHE ACHE Oxime Bisquaternary Alkyl linked bis-ligand
6o-5-HT3 BCHE ACHE Multitarget 5-HT-receptor-ligand Derivative of Tacrine Carboxamide Alkyl linked bis-ligand
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
6ZWE-Cpd3 BCHE ACHE Multitarget Antioxidant Benzodioxo Alkyl linked bis-ligand
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
Memoquin ACHE Multitarget BACE1-inhibitor Antioxidant Alkyl linked bis-ligand
Lipocrine ACHE Multitarget Derivative of Tacrine Antioxidant Sulfur Compound Alkyl linked bis-ligand
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
N-saccharinohexylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur Compound
bis9-(-)-nor-meptazinol ACHE Alkyl linked bis-ligand Azepane
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
NP61 BCHE ACHE Indole Derivative of Tacrine Alkyl linked bis-ligand
Memagal ACHE Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand Benzazepin Azepane
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol Derivative of Tacrine NMDA-Ligand
ARN14140-doubleboundlink ACHE Adamantyl Alkyl linked bis-ligand Multitarget Derivative of Galanthamine NMDA-Ligand Azepane
ARN14140 ACHE Adamantyl Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Alkyl linked bis-ligand
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
Tacrine-Trolox-7u ACHE Multitarget Antioxidant Derivative of Tacrine Carboxamide Alkyl linked bis-ligand Chromen
CB1R-ACHE-20 ACHE Multitarget Cannabinoid-Receptor-ligand Derivative of Tacrine Imidazole Carboxamide Alkyl linked bis-ligand
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole
Tacrine-nicotinamide ACHE Derivative of Tacrine Derivative of Nicotine Alkyl linked bis-ligand Nicotinamide Carboxamide
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Tacrine-Melatonin-Feruloyl-5c BCHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
Tacrine(8)-4-aminoquinoline ACHE Derivative of Tacrine Quinoline Alkyl linked bis-ligand
Aroylacrylic-acid-amide-Tacrine-10 ACHE BCHE Derivative of Tacrine Alkyl linked bis-ligand
NF595 ACHE Derivative of Tacrine Alkyl linked bis-ligand Sulfur Compound
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Tz2Pa6-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-syn1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
TZ2PIQA5 ACHE Acridine Quinoline Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa6-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tz2Pa5-anti1 ACHE Acridine Phenanthridinium Derivative of Tacrine Alkyl linked bis-ligand Triazol
Tacrine-Benzofuran ACHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
Bis5-tacrine ACHE Derivative of Tacrine Acridine Alkyl linked bis-ligand
Bis7-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
Bis3-tacrine ACHE Derivative of Tacrine Alkyl linked bis-ligand Acridine
CHEMBL4456083 Derivative of Tacrine Alkyl linked bis-ligand Acridine Benzimidazole Carboxamide
Bis-galanthamine ACHE Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepane Natural_modified
hBChE-IN-1-Cpd4 BCHE Quinolizine Xanthene Sulfur Compound Multitarget Alkyl linked bis-ligand
Gamma-carboline-nonyl-bivalent beta-carboline Indole NMDA-Ligand Multitarget Alkyl linked bis-ligand
Bis-alkylene-Amiridine-3c Derivative of Amiridine Quinoline Alkyl linked bis-ligand
(R)-Tacrine(10)-Hupyridone ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Alkyl linked bis-ligand
(S,S)-(-)-bis(12)-hupyridone ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand
(S,S)-(-)-bis(10)-hupyridone ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand