CHEMBL4466019
BChE IC50 3.1 microM; MAO-B IC50 1.3 microM; Inhibit self-induced A1-42 aggregation with 63.9%, potent antioxidant agent and neuroprotectant; selective metal chelator (Cu2+ and Al3+); inhibits and disaggregates Cu2+-induced Abeta1-42 aggregation
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Carbamate
Chemical_Nomenclature : [3-[(E)-3-(2-hydroxyphenyl)-3-oxoprop-1-enyl]phenyl] N-ethyl-N-methylcarbamate
Canonical SMILES : CCN(C)C(=O)OC1=CC=CC(=C1)\/C=C\/C(=O)C2=CC=CC=C2O
InChI : InChI=1S\/C19H19NO4\/c1-3-20(2)19(23)24-15-8-6-7-14(13-15)11-12-18(22)16-9-4-5-10-17(16)21\/h4-13,21H,3H2,1-2H3\/b12-11+
InChIKey : MFXKQHXOACNCJP-VAWYXSNFSA-N
Other name(s) : BDBM50504425 || Compounds 5b
MW : 325.4
Formula : C19H19NO4
CAS_number :
PubChem : 155531521
UniChem : MFXKQHXOACNCJP-VAWYXSNFSA-N
Target
Families : CHEMBL4466019 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (2)
| Title : Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease - Sang_2019_Eur.J.Med.Chem_178_726 |
| Author(s) : Sang Z , Wang K , Shi J , Liu W , Tan Z |
| Ref : Eur Journal of Medicinal Chemistry , 178 :726 , 2019 |
| Abstract : |
| PubMedSearch : Sang_2019_Eur.J.Med.Chem_178_726 |
| PubMedID: 31229875 |
| Title : Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease - Bai_2019_Eur.J.Med.Chem_183_111737 |
| Author(s) : Bai P , Wang K , Zhang P , Shi J , Cheng X , Zhang Q , Zheng C , Cheng Y , Yang J , Lu X , Sang Z |
| Ref : Eur Journal of Medicinal Chemistry , 183 :111737 , 2019 |
| Abstract : |
| PubMedSearch : Bai_2019_Eur.J.Med.Chem_183_111737 |
| PubMedID: 31581002 |