CHEMBL4797670
IC50 AChE microM 0.14 (0.110.17); IC50 BChE microM 3.84 (3.174.54) || Derivative of Chelerythrine, Sanguinarine. Sanguinarine is a benzophenanthridine alkaloid, an alkaloid antibiotic and a botanical anti-fungal agent.
General
Type : Isoquinoline, Alkaloid, Quinoline
Chemical_Nomenclature : 8-methoxy-2-(4-methoxyphenyl)isoquinolin-2-ium\;bromide
Canonical SMILES : COC1=CC=C(C=C1)[N+]2=CC3=C(C=CC=C3OC)C=C2.[Br-]
InChI : InChI=1S\/C17H16NO2.BrH\/c1-19-15-8-6-14(7-9-15)18-11-10-13-4-3-5-17(20-2)16(13)12-18\;\/h3-12H,1-2H3\;1H\/q+1\;\/p-18-Methoxy-2-(4-methoxyphenyl)isoquinolin-2-ium bromide
InChIKey : RLNCOEXWGNQPIF-UHFFFAOYSA-M
Other name(s) : BDBM50564856 || Compound 8y
MW : 346.2
Formula : C17H16BrNO2
CAS_number :
PubChem : 162675254
UniChem : RLNCOEXWGNQPIF-UHFFFAOYSA-M
Target
Families : CHEMBL4797670 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase - Zhou_2020_Eur.J.Med.Chem_200_112415 |
| Author(s) : Zhou B , Li H , Cui Z , Li D , Geng H , Gao J , Zhou L |
| Ref : Eur Journal of Medicinal Chemistry , 200 :112415 , 2020 |
| Abstract : |
| PubMedSearch : Zhou_2020_Eur.J.Med.Chem_200_112415 |
| PubMedID: 32454229 |