CHEMBL5195416
Pyridoxine-resveratrol hybrids Mannich base derivative dual inhibitor of AChE and MAO-B with antioxidant and metal-chelating properties. IC50 ACHE 2.11 +/- 0.10; BCHE 16.7 +/- 0.63; MAO-B 12.4 +/- 0.36; MAO-A 12.8 +/- 0.32 microM
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Piperidine, Antioxidant
Chemical_Nomenclature : 4-(hydroxymethyl)-5-[(E)-2-[3-hydroxy-4-(piperidin-1-ylmethyl)phenyl]ethenyl]-2-methylpyridin-3-ol
Canonical SMILES : CC1=NC=C(C(=C1O)CO)\/C=C\/C2=CC(=C(C=C2)CN3CCCCC3)O
InChI : InChI=1S\/C21H26N2O3\/c1-15-21(26)19(14-24)17(12-22-15)7-5-16-6-8-18(20(25)11-16)13-23-9-3-2-4-10-23\/h5-8,11-12,24-26H,2-4,9-10,13-14H2,1H3\/b7-5+
InChIKey : USIJOWDRRISYGX-FNORWQNLSA-N
Other name(s) : BDBM222336 || Compound 7d
MW : 354.4
Formula : C21H26N2O3
CAS_number :
PubChem : 126842839
UniChem : USIJOWDRRISYGX-FNORWQNLSA-N
Target
Families : CHEMBL5195416 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease - Yang_2017_Bioorg.Chem_71_305 |
| Author(s) : Yang X , Qiang X , Li Y , Luo L , Xu R , Zheng Y , Cao Z , Tan Z , Deng Y |
| Ref : Bioorg Chem , 71 :305 , 2017 |
| Abstract : |
| PubMedSearch : Yang_2017_Bioorg.Chem_71_305 |
| PubMedID: 28267984 |