Carbazole-acrylamide-pyridinium-cpd12g
AChE IC50 9.94 +/- 0.18 nM; BChE IC50 38.05 +/- 0.27 nM
General
Type : Carbazol, Acrylate, Pyridine, Pyridinium
Chemical_Nomenclature : E-3-((3-(9-Benzyl-9H-carbazol-3-yl)acrylamido)methyl)-1-(2-((4-chlorophenyl)amino)-2-oxoethyl)pyridin-1-ium chloride
Canonical SMILES : C16=C([N](C2=C1C=C(C=C2)C=CC(NCC3=CC=C[N+](=C3)CC(=O)NC4=CC=C(C=C4)Cl)=O)CC5=CC=CC=C5)C=CC=C6.[Cl-]
InChI : InChI=1S\/2C36H29ClN4O2.2ClH\/c2*37-29-14-16-30(17-15-29)39-36(43)25-40-20-6-9-28(23-40)22-38-35(42)19-13-26-12-18-34-32(21-26)31-10-4-5-11-33(31)41(34)24-27-7-2-1-3-8-27\;\;\/h2*1-21,23H,22,24-25H2,(H-,38,39,42,43)\;2*1H
InChIKey : ZIITYAZNLVRTMK-UHFFFAOYSA-N
Other name(s) : Compound 12g
Target
Families : Carbazole-acrylamide-pyridinium-cpd12g ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Design and synthesis of carbazole-acrylamide-pyridinium hybrids as dual acetylcholinesterase\/butyrylcholinesterase inhibitors and evaluation of their cytotoxic profile on SH-SY5Y and HEK293 cell lines - Taherkhani_2026_RSC.Med.Chem__ |
| Author(s) : Taherkhani AM , Senol H , Valizadeh Y , Ghafouri SN , Dastyafteh N , Aktas A , Sadeghian N , Moradkhani F , Larijani B , Biglar M , Taslimi P , Mohammadi-Khanaposhtani M , Mahdavi M |
| Ref : RSC Med Chem , : , 2026 |
| Abstract : |
| PubMedSearch : Taherkhani_2026_RSC.Med.Chem__ |
| PubMedID: 42824777 |