ChEs-MAOs-IN-1
4i, (E)-N'-(2,3-dichlorobenzylidene)benzo[d][1,3]dioxole-5-carbohydrazide showed promising dual inhibitory profile against AChE (0.048 +/- 0.007 M), BChE (0.89 +/- 0.018 M), and MAO-B (0.95 +/- 0.12 M)
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Benzodioxo, Carboxamide
Chemical_Nomenclature : N-[(E)-(2,3-dichlorophenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide
Canonical SMILES : C1OC2=C(O1)C=C(C=C2)C(=O)NN=CC3=C(C(=CC=C3)Cl)Cl
InChI : InChI=1S\/C15H10Cl2N2O3\/c16-11-3-1-2-10(14(11)17)7-18-19-15(20)9-4-5-12-13(6-9)22-8-21-12\/h1-7H,8H2,(H,19,20)\/b18-7+
InChIKey : WFEICUTYOGADAP-CNHKJKLMSA-N
Other name(s) : ChEs\/MAOs-IN-1 || AKOS003871002 || HY-162061 || CS-0912055 || (e)-N'-(2,3-dichlorobenzylidene)benzo[d][1,3]dioxole-5-carbohydrazide || Compound 4i
MW : 337.2
Formula : C15H10Cl2N2O3
CAS_number :
PubChem : 9626818
UniChem : WFEICUTYOGADAP-CNHKJKLMSA-N
Target
References (1)
| Title : Exploration of a library of piperonylic acid-derived hydrazones possessing variable aryl functionalities as potent dual cholinesterase and monoamine oxidase inhibitors - Kumar_2022_Mol.Divers__ |
| Author(s) : Kumar VP , Vishnu MS , Kumar S , Jaiswal S , Ayyannan SR |
| Ref : Mol Divers , : , 2022 |
| Abstract : |
| PubMedSearch : Kumar_2022_Mol.Divers__ |
| PubMedID: 36355337 |