Cryptotanshinone
Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent
General
Type : Benzofuran, Natural, Tanshinone
Chemical_Nomenclature : (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione
Canonical SMILES : C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
InChI : InChI=1S\/C19H20O3\/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18\/h6-7,10H,4-5,8-9H2,1-3H3\/t10-\/m0\/s1
InChIKey : GVKKJJOMQCNPGB-JTQLQIEISA-N
Other name(s) : Tanshinone c || Cryptotanshinon || (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione || (15R)-cryptotanshinone || C19H20O3 || UNII-5E9SXT166N
MW : 296.4
Formula : C19H20O3
CAS_number : 35825-57-1
PubChem : 160254
UniChem : GVKKJJOMQCNPGB-JTQLQIEISA-N
Target
Families : Cryptotanshinone ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (27)
| Title : Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling - Deng_2022_Front.Pharmacol_13_941522 |
| Author(s) : Deng H , Zhang Q , Lei Q , Yang N , Yang K , Jiang J , Yu Z |
| Ref : Front Pharmacol , 13 :941522 , 2022 |
| Abstract : |
| PubMedSearch : Deng_2022_Front.Pharmacol_13_941522 |
| PubMedID: 36105202 |
| Title : Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling - Deng_2022_Front.Pharmacol_13_941522 |
| Author(s) : Deng H , Zhang Q , Lei Q , Yang N , Yang K , Jiang J , Yu Z |
| Ref : Front Pharmacol , 13 :941522 , 2022 |
| Abstract : |
| PubMedSearch : Deng_2022_Front.Pharmacol_13_941522 |
| PubMedID: 36105202 |
| Title : Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling - Deng_2022_Front.Pharmacol_13_941522 |
| Author(s) : Deng H , Zhang Q , Lei Q , Yang N , Yang K , Jiang J , Yu Z |
| Ref : Front Pharmacol , 13 :941522 , 2022 |
| Abstract : |
| PubMedSearch : Deng_2022_Front.Pharmacol_13_941522 |
| PubMedID: 36105202 |
| Title : Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth - Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Slusarczyk S , Senol Deniz FS , Abel R , Pecio L , Perez-Sanchez H , Ceron-Carrasco JP , den-Haan H , Banerjee P , Preissner R , Krzyzak E , Oleszek W , I EO , Matkowski A |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32586060 |
| Title : Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth - Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Slusarczyk S , Senol Deniz FS , Abel R , Pecio L , Perez-Sanchez H , Ceron-Carrasco JP , den-Haan H , Banerjee P , Preissner R , Krzyzak E , Oleszek W , I EO , Matkowski A |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32586060 |
| Title : Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth - Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Slusarczyk S , Senol Deniz FS , Abel R , Pecio L , Perez-Sanchez H , Ceron-Carrasco JP , den-Haan H , Banerjee P , Preissner R , Krzyzak E , Oleszek W , I EO , Matkowski A |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Slusarczyk_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32586060 |
| Title : Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors - Marrelli_2019_Nat.Prod.Res__1 |
| Author(s) : Marrelli M , Grande F , Occhiuzzi MA , Maione F , Mascolo N , Conforti F |
| Ref : Nat Prod Res , :1 , 2019 |
| Abstract : |
| PubMedSearch : Marrelli_2019_Nat.Prod.Res__1 |
| PubMedID: 31104489 |
| Title : Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors - Marrelli_2019_Nat.Prod.Res__1 |
| Author(s) : Marrelli M , Grande F , Occhiuzzi MA , Maione F , Mascolo N , Conforti F |
| Ref : Nat Prod Res , :1 , 2019 |
| Abstract : |
| PubMedSearch : Marrelli_2019_Nat.Prod.Res__1 |
| PubMedID: 31104489 |
| Title : Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors - Marrelli_2019_Nat.Prod.Res__1 |
| Author(s) : Marrelli M , Grande F , Occhiuzzi MA , Maione F , Mascolo N , Conforti F |
| Ref : Nat Prod Res , :1 , 2019 |
| Abstract : |
| PubMedSearch : Marrelli_2019_Nat.Prod.Res__1 |
| PubMedID: 31104489 |
| Title : Bioprofiling of Salvia miltiorrhiza via planar chromatography linked to (bio)assays, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy - Azadniya_2018_J.Chromatogr.A_1533_180 |
| Author(s) : Azadniya E , Morlock GE |
| Ref : Journal of Chromatography A , 1533 :180 , 2018 |
| Abstract : |
| PubMedSearch : Azadniya_2018_J.Chromatogr.A_1533_180 |
| PubMedID: 29258686 |
| Title : Bioprofiling of Salvia miltiorrhiza via planar chromatography linked to (bio)assays, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy - Azadniya_2018_J.Chromatogr.A_1533_180 |
| Author(s) : Azadniya E , Morlock GE |
| Ref : Journal of Chromatography A , 1533 :180 , 2018 |
| Abstract : |
| PubMedSearch : Azadniya_2018_J.Chromatogr.A_1533_180 |
| PubMedID: 29258686 |
| Title : Bioprofiling of Salvia miltiorrhiza via planar chromatography linked to (bio)assays, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy - Azadniya_2018_J.Chromatogr.A_1533_180 |
| Author(s) : Azadniya E , Morlock GE |
| Ref : Journal of Chromatography A , 1533 :180 , 2018 |
| Abstract : |
| PubMedSearch : Azadniya_2018_J.Chromatogr.A_1533_180 |
| PubMedID: 29258686 |
| Title : Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L - Senol_2017_Phytochemistry_133_33 |
| Author(s) : Senol FS , Slusarczyk S , Matkowski A , Perez-Garrido A , Giron-Rodriguez F , Ceron-Carrasco JP , den-Haan H , Pena-Garcia J , Perez-Sanchez H , Domaradzki K , Orhan IE |
| Ref : Phytochemistry , 133 :33 , 2017 |
| Abstract : |
| PubMedSearch : Senol_2017_Phytochemistry_133_33 |
| PubMedID: 27817931 |
| Title : Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L - Senol_2017_Phytochemistry_133_33 |
| Author(s) : Senol FS , Slusarczyk S , Matkowski A , Perez-Garrido A , Giron-Rodriguez F , Ceron-Carrasco JP , den-Haan H , Pena-Garcia J , Perez-Sanchez H , Domaradzki K , Orhan IE |
| Ref : Phytochemistry , 133 :33 , 2017 |
| Abstract : |
| PubMedSearch : Senol_2017_Phytochemistry_133_33 |
| PubMedID: 27817931 |
| Title : Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L - Senol_2017_Phytochemistry_133_33 |
| Author(s) : Senol FS , Slusarczyk S , Matkowski A , Perez-Garrido A , Giron-Rodriguez F , Ceron-Carrasco JP , den-Haan H , Pena-Garcia J , Perez-Sanchez H , Domaradzki K , Orhan IE |
| Ref : Phytochemistry , 133 :33 , 2017 |
| Abstract : |
| PubMedSearch : Senol_2017_Phytochemistry_133_33 |
| PubMedID: 27817931 |
| Title : Terpenoids as potential anti-Alzheimer's disease therapeutics - Yoo_2012_Molecules_17_3524 |
| Author(s) : Yoo KY , Park SY |
| Ref : Molecules , 17 :3524 , 2012 |
| Abstract : |
| PubMedSearch : Yoo_2012_Molecules_17_3524 |
| PubMedID: 22430119 |
| Title : Terpenoids as potential anti-Alzheimer's disease therapeutics - Yoo_2012_Molecules_17_3524 |
| Author(s) : Yoo KY , Park SY |
| Ref : Molecules , 17 :3524 , 2012 |
| Abstract : |
| PubMedSearch : Yoo_2012_Molecules_17_3524 |
| PubMedID: 22430119 |
| Title : Terpenoids as potential anti-Alzheimer's disease therapeutics - Yoo_2012_Molecules_17_3524 |
| Author(s) : Yoo KY , Park SY |
| Ref : Molecules , 17 :3524 , 2012 |
| Abstract : |
| PubMedSearch : Yoo_2012_Molecules_17_3524 |
| PubMedID: 22430119 |
| Title : Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis - Wong_2010_Chem.Biol.Interact_187_335 |
| Author(s) : Wong KK , Ngo JC , Liu S , Lin HQ , Hu C , Shaw PC , Wan DC |
| Ref : Chemico-Biological Interactions , 187 :335 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Chem.Biol.Interact_187_335 |
| PubMedID: 20350537 |
| Title : Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task - Wong_2010_Planta.Med_76_228 |
| Author(s) : Wong KK , Ho MT , Lin HQ , Lau KF , Rudd JA , Chung RC , Fung KP , Shaw PC , Wan DC |
| Ref : Planta Med , 76 :228 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Planta.Med_76_228 |
| PubMedID: 19774505 |
| Title : Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis - Wong_2010_Chem.Biol.Interact_187_335 |
| Author(s) : Wong KK , Ngo JC , Liu S , Lin HQ , Hu C , Shaw PC , Wan DC |
| Ref : Chemico-Biological Interactions , 187 :335 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Chem.Biol.Interact_187_335 |
| PubMedID: 20350537 |
| Title : Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task - Wong_2010_Planta.Med_76_228 |
| Author(s) : Wong KK , Ho MT , Lin HQ , Lau KF , Rudd JA , Chung RC , Fung KP , Shaw PC , Wan DC |
| Ref : Planta Med , 76 :228 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Planta.Med_76_228 |
| PubMedID: 19774505 |
| Title : Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis - Wong_2010_Chem.Biol.Interact_187_335 |
| Author(s) : Wong KK , Ngo JC , Liu S , Lin HQ , Hu C , Shaw PC , Wan DC |
| Ref : Chemico-Biological Interactions , 187 :335 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Chem.Biol.Interact_187_335 |
| PubMedID: 20350537 |
| Title : Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task - Wong_2010_Planta.Med_76_228 |
| Author(s) : Wong KK , Ho MT , Lin HQ , Lau KF , Rudd JA , Chung RC , Fung KP , Shaw PC , Wan DC |
| Ref : Planta Med , 76 :228 , 2010 |
| Abstract : |
| PubMedSearch : Wong_2010_Planta.Med_76_228 |
| PubMedID: 19774505 |
| Title : Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza - Ren_2004_Planta.Med_70_201 |
| Author(s) : Ren Y , Houghton PJ , Hider RC , Howes MJ |
| Ref : Planta Med , 70 :201 , 2004 |
| Abstract : |
| PubMedSearch : Ren_2004_Planta.Med_70_201 |
| PubMedID: 15114495 |
| Title : Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza - Ren_2004_Planta.Med_70_201 |
| Author(s) : Ren Y , Houghton PJ , Hider RC , Howes MJ |
| Ref : Planta Med , 70 :201 , 2004 |
| Abstract : |
| PubMedSearch : Ren_2004_Planta.Med_70_201 |
| PubMedID: 15114495 |
| Title : Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza - Ren_2004_Planta.Med_70_201 |
| Author(s) : Ren Y , Houghton PJ , Hider RC , Howes MJ |
| Ref : Planta Med , 70 :201 , 2004 |
| Abstract : |
| PubMedSearch : Ren_2004_Planta.Med_70_201 |
| PubMedID: 15114495 |