DCJW

Product of hydrolysis of Indoxacarb || Indoxacarb acts against lepidopteran larvae. It has a role as a voltage-gated sodium channel blocker. In 2021, the European Union chose not to renew Indoxacarb for use as an insecticide. The United Kingdom still allows use of the compound until 2025. N-decarbomethoxylated metabolite (DCJW) is teh active compound. Indoxacarb is degraded by SlituCOE067 into DCJW. Down regulation of this carboxylesterase reduced the sensitivity of larvae to indoxacarb. Overexpression has the opposite effect Shi et al 2025

General

Type : Insecticide, Carboxamide, Carbamate, Trifluoro, Not AlphaBeta Hydrolase target

Chemical_Nomenclature : methyl (4aS)-7-chloro-2-[[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate

Canonical SMILES : COC(=O)[C@]12CC3=C(C1=NN(CO2)C(=O)NC4=CC=C(C=C4)OC(F)(F)F)C=CC(=C3)Cl

InChI : InChI=1S\/C20H15ClF3N3O5\/c1-30-17(28)19-9-11-8-12(21)2-7-15(11)16(19)26-27(10-31-19)18(29)25-13-3-5-14(6-4-13)32-20(22,23)24\/h2-8H,9-10H2,1H3,(H,25,29)\/t19-\/m0\/s1

InChIKey : ZQBDNGWVXFMUHC-IBGZPJMESA-N

Other name(s) : (S)-Indoxacarb metabolite IN-JT 333 || \; Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid,7-chloro-2,5-dihydro-2-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]- methyl ester, (S)- || DCJW || N-Decarboxymethylated indoxacarb || SCHEMBL22310340 || indoxacarb TP1

MW : 469.8

Formula : C20H15ClF3N3O5

CAS_number : 200568-74-7

PubChem : 149549437, 155884405, 67792912

UniChem : ZQBDNGWVXFMUHC-IBGZPJMESA-N