Dimethyl-pyrazolopyridine-Ethyl-methyl-triazole-carboxylate-Cpd23
IC50 hAChE 0.056 +/- 0.002 microM GSK3beta inhibitory. Ethyl ester so precursor of compound 31
General
Type : Pyridine, Pyrazole, Triazol, GSK-3 kinase inhibitor, Multitarget
Chemical_Nomenclature : 4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine - Ethyl 5-methyl-1H-1,2,3-triazole-4-carboxylate
Canonical SMILES : CCOC(C3=C(C)[N](C1=N[N](C2=C1C(=CC(=N2)C)C)[H])N=N3)=O
InChI : InChI=1S\/C14H16N6O2\/c1-5-22-14(21)11-9(4)20(19-16-11)13-10-7(2)6-8(3)15-12(10)17-18-13\/h6H,5H2,1-4H3,(H,15,17,18)
InChIKey : DKWFCUFSYXHQPS-UHFFFAOYSA-N
Other name(s) : Compound 23
Target
Families : Dimethyl-pyrazolopyridine-Ethyl-methyl-triazole-carboxylate-Cpd23 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Pyrazolopyridine-Containing Compounds as Multitargeted Anti-Alzheimer Agents: Synthesis, Biological Evaluation, and In Silico Studies - Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| Author(s) : Waly OM , El-Sayed SM , Ghaly MA , El-Subbagh HI |
| Ref : Arch Pharm (Weinheim) , 358 :e70025 , 2025 |
| Abstract : |
| PubMedSearch : Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| PubMedID: 40544486 |
| Title : Pyrazolopyridine-Containing Compounds as Multitargeted Anti-Alzheimer Agents: Synthesis, Biological Evaluation, and In Silico Studies - Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| Author(s) : Waly OM , El-Sayed SM , Ghaly MA , El-Subbagh HI |
| Ref : Arch Pharm (Weinheim) , 358 :e70025 , 2025 |
| Abstract : |
| PubMedSearch : Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| PubMedID: 40544486 |
| Title : Pyrazolopyridine-Containing Compounds as Multitargeted Anti-Alzheimer Agents: Synthesis, Biological Evaluation, and In Silico Studies - Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| Author(s) : Waly OM , El-Sayed SM , Ghaly MA , El-Subbagh HI |
| Ref : Arch Pharm (Weinheim) , 358 :e70025 , 2025 |
| Abstract : |
| PubMedSearch : Waly_2025_Arch.Pharm.(Weinheim)_358_e70025 |
| PubMedID: 40544486 |