GSK-3 kinase inhibitor

General

Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology. Multi targets inhibitors have been developped in order to inhibit both GSK-3 kinase and cholinesterases as well as other pathways

Inhibitor	Main targeted enzyme families	Type
AJ-4	ACHE	Thiadiazol Sulfur Compound GSK-3 kinase inhibitor Carbamate Multitarget
Oxo-chromen-iminomethyl-phenoxy-phenylacetamide-Cpd10f	ACHE BCHE	Multitarget Chromen GSK-3 kinase inhibitor Coumarin
Thiophen-amino-chromen-2-one-Cpd6h	ACHE BCHE	Chromen Sulfur Compound Thiophen GSK-3 kinase inhibitor anti-tau-aggregation Multitarget
Cyclohexylaminopropyl-Kenpaullone-carboxamide-Cpd18o	ACHE	GSK-3 kinase inhibitor Multitarget Indole Carboxamide Azepane
Dimethyl-pyrazolopyridine-Ethyl-methyl-triazole-carboxylate-Cpd23	ACHE	Pyridine Pyrazole Triazol GSK-3 kinase inhibitor Multitarget
Methoxybenzoxazol-tacrine-cpd44	ACHE	Benzoxazol Derivative of Tacrine Acridine Multitarget GSK-3 kinase inhibitor anti-Abeta-aggregation
CHEMBL4278686	ACHE	GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur Compound
ZTL-11	ACHE	GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23	ACHE	Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
TDZD8	Pectinacetylesterase-Notum	Not AlphaBeta Hydrolase target GSK-3 kinase inhibitor Thiadiazol Sulfur Compound
ACHE-GSK-3-27g	ACHE	GSK-3 kinase inhibitor Derivative of Tacrine Acridine Multitarget
BIGI-3h	ACHE BCHE	Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Benzylpiperidine Derivative of Donepezil Organochlorine
6H12-(R)2	ACHE	Derivative of Tacrine Acridine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Triazol
6H13-(R)3	ACHE	Derivative of Tacrine Acridine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Triazol
FG1912	ACHE	GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29	ACHE	GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
GT15	ACHE	Derivative of Tacrine Acridine GSK-3 kinase inhibitor Sulfur Compound Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6	ACHE	Derivative of Tacrine Acridine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Triazol
hAChE-IN-6	BCHE ACHE	Pyridine Pyrazole GSK-3 kinase inhibitor anti-tau-aggregation Multitarget Dimethoxyphenyl