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GSK-3 kinase inhibitor

General

Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology. Multi targets inhibitors have been developped in order to inhibit both GSK-3 kinase and cholinesterases as well as other pathways
Inhibitor Main targeted enzyme families Type Structure
CHEMBL4278686 ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget Thiazole Carboxamide Pyridine Cyclopropyl Sulfur Compound
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
TDZD8 Pectinacetylesterase-Notum Not A\/B H target GSK-3 kinase inhibitor Thiadiazol Sulfur Compound
ACHE-GSK-3-27g ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
hAChE-IN-6 BCHE ACHE Pyridine Pyrazole GSK-3 kinase inhibitor Multitarget