GSK-3 kinase inhibitor

General

Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology. Multi targets inhibitors have been developped in order to inhibit both GSK-3 kinase and cholinesterases as well as other pathways

Inhibitor	Main targeted enzyme familyes	Type
ZTL-11	ACHE	GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23	ACHE	Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
TDZD8	Pectinacetylesterase-Notum	Not A\/B H target GSK-3 kinase inhibitor Thiadiazol Sulfur Compound
ACHE-GSK-3-27g	ACHE	GSK-3 kinase inhibitor Derivative of Tacrine Multitarget
BIGI-3h	ACHE BCHE	Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
6H12-(R)2	ACHE	Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3	ACHE	Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
FG1912		GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29	ACHE	GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15	ACHE	Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6	ACHE	Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
hAChE-IN-6		Pyridine Pyrazole GSK-3 kinase inhibitor Multitarget