Doxacurium
Interaction of doxacurium with cholinesterase not clinically relevent .neuromuscular non depolarising blocking drug, benzylisoquinolines resembling atracurium, benzylisoquinolinium diester. Bis quaternary
General
Type : Neuromuscular Nondepolarizing Agents, Isoquinoline, Bisquaternary, Not A\/B H target
Chemical_Nomenclature : bis[3-[(1S)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] butanedioate dichloride
Canonical SMILES : C[N+]1(CCC2=CC(=C(C(=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)OC)CCCOC(=O)CCC(=O)OCCC[N+]4(CCC5=CC(=C(C(=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]
InChI : InChI=1S\/C56H78N2O16.2ClH\/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6\;\;\/h29-34,39-40H,15-28H2,1-14H3\;2*1H\/q+2\;\;\/p-2
InChIKey : APADFLLAXHIMFU-UHFFFAOYSA-L
Other name(s) : Nuromax || BW A938U
MW : 1035.22
Formula : C56H78N2O16
CAS_number : 106819-53-8
UniChem : APADFLLAXHIMFU-UHFFFAOYSA-L
Wikipedia : Doxacurium_chloride
Target
Families : Doxacurium ligand of proteins in family
BCHE
References (3)
| Title : Clinical pharmacokinetics of the newer neuromuscular blocking drugs - Atherton_1999_Clin.Pharmacokinet_36_169 |
| Author(s) : Atherton DP , Hunter JM |
| Ref : Clinical Pharmacokinetics , 36 :169 , 1999 |
| Abstract : |
| PubMedSearch : Atherton_1999_Clin.Pharmacokinet_36_169 |
| PubMedID: 10223167 |
| Title : New neuromuscular blocking drugs [see comments] - Hunter_1995_N.Engl.J.Med_332_1691 |
| Author(s) : Hunter JM |
| Ref : N Engl J Med , 332 :1691 , 1995 |
| Abstract : |
| PubMedSearch : Hunter_1995_N.Engl.J.Med_332_1691 |
| PubMedID: 7760871 |
| Title : Newer neuromuscular blocking agents - Bevan_1994_Pharmacol.Toxicol_74_3 |
| Author(s) : Bevan DR |
| Ref : Pharmacol Toxicol , 74 :3 , 1994 |
| Abstract : |
| PubMedSearch : Bevan_1994_Pharmacol.Toxicol_74_3 |
| PubMedID: 8159634 |