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Bisquaternary

General

The bisquaternary ligand are oriented along the narrow gorge of AChE leading to the active site; one quaternary group is apposed to the indole of Trp-84 and the other to that of Trp-279, near the top of the gorge. Ligands of both the CAS (catalytic active site) and the PAS (peripheral active site). The PAS is supposed to be part of some of the non catalytic properties od ACHEs
Inhibitor Main targeted enzyme families Type Structure
2,6-bis(N-methylpyridinium-3-ylmethylene)cyclohexanone-Cpd2A ACHE Bisquaternary Pyridine
CHEMBL3313966 ACHE Bisquaternary Pyridine
EA-4056 ACHE Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990 ACHE Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ ACHE Analogue of substrate Trimethylammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
N-alkyl-quinuclidine-cpd14 BCHE ACHE Oxime Bisquaternary Alkyl linked bis-ligand
Demecarium ACHE BCHE Trimethylammonium Bisquaternary Drug
C-547 ACHE Bisquaternary Pyrimidine Trimethylammonium Uracil derivative
Ambenonium BCHE Bisquaternary Drug
BW62C47 ACHE Bisquaternary Trimethylammonium
BW284C51 ACHE Bisquaternary
Decamethonium BCHE Bisquaternary Trimethylammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium ACHE Bisquaternary Trimethylammonium Phenanthridinium Derivative of Propidium
Hexamethonium ACHE Bisquaternary Nicotinic antagonist Trimethylammonium
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Succinylcholine~Suxamethonium BCHE Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Not AlphaBeta Hydrolase target
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target