Bisquaternary

General

The bisquaternary ligand are oriented along the narrow gorge of AChE leading to the active site; one quaternary group is apposed to the indole of Trp-84 and the other to that of Trp-279, near the top of the gorge. Ligands of both the CAS (catalytic active site) and the PAS (peripheral active site). The PAS is supposed to be part of some of the non catalytic properties od ACHEs

Inhibitor	Main targeted enzyme families	Type
2,6-bis(N-methylpyridinium-3-ylmethylene)cyclohexanone-Cpd2A	ACHE	Bisquaternary Pyridine
CHEMBL3313966	ACHE	Bisquaternary Pyridine Hydrazinylidene Organochlorine
EA-4056	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3966	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ	ACHE	Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
N-alkyl-quinuclidine-cpd14	BCHE ACHE	Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
Demecarium	ACHE BCHE	Trimethylammonium Ammonium Bisquaternary Drug
Mylaxen	BCHE	Neuromuscular Nondepolarizing Agents Drug Fluoren Ammonium Bisquaternary
C-547	ACHE	Bisquaternary Pyrimidine Ammonium Uracil derivative
Ambenonium	BCHE	Bisquaternary Drug Organochlorine
BW62C47	ACHE	Bisquaternary Trimethylammonium Ammonium
BW284C51	ACHE	Bisquaternary
Decamethonium	BCHE	Bisquaternary Trimethylammonium Ammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium	ACHE	Bisquaternary Trimethylammonium Ammonium Phenanthridinium Derivative of Propidium
Hexamethonium	ACHE	Bisquaternary Nicotinic antagonist Trimethylammonium Ammonium
Mivacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Succinylcholine~Suxamethonium	BCHE	Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Ammonium Not AlphaBeta Hydrolase target
Doxacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium	BCHE	Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target
2,6-bis(N-methylpyridinium-3-ylmethylene)cyclohexanone-Cpd2A	ACHE	Bisquaternary Pyridine
CHEMBL3313966	ACHE	Bisquaternary Pyridine Hydrazinylidene Organochlorine
EA-4056	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3966	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ	ACHE	Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
N-alkyl-quinuclidine-cpd14	BCHE ACHE	Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
Demecarium	ACHE BCHE	Trimethylammonium Ammonium Bisquaternary Drug
Mylaxen	BCHE	Neuromuscular Nondepolarizing Agents Drug Fluoren Ammonium Bisquaternary
C-547	ACHE	Bisquaternary Pyrimidine Ammonium Uracil derivative
Ambenonium	BCHE	Bisquaternary Drug Organochlorine
BW62C47	ACHE	Bisquaternary Trimethylammonium Ammonium
BW284C51	ACHE	Bisquaternary
Decamethonium	BCHE	Bisquaternary Trimethylammonium Ammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium	ACHE	Bisquaternary Trimethylammonium Ammonium Phenanthridinium Derivative of Propidium
Hexamethonium	ACHE	Bisquaternary Nicotinic antagonist Trimethylammonium Ammonium
Mivacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Succinylcholine~Suxamethonium	BCHE	Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Ammonium Not AlphaBeta Hydrolase target
Doxacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium	BCHE	Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target
2,6-bis(N-methylpyridinium-3-ylmethylene)cyclohexanone-Cpd2A	ACHE	Bisquaternary Pyridine
CHEMBL3313966	ACHE	Bisquaternary Pyridine Hydrazinylidene Organochlorine
EA-4056	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990	ACHE	Carbamate Chemical Warfare Agent Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3966	ACHE	Carbamate Chemical Warfare Agent Trimethylammonium Ammonium Bisquaternary Nerve Agent Carbamate Pyridine
BisQ	ACHE	Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
N-alkyl-quinuclidine-cpd14	BCHE ACHE	Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
Demecarium	ACHE BCHE	Trimethylammonium Ammonium Bisquaternary Drug
Mylaxen	BCHE	Neuromuscular Nondepolarizing Agents Drug Fluoren Ammonium Bisquaternary
C-547	ACHE	Bisquaternary Pyrimidine Ammonium Uracil derivative
Ambenonium	BCHE	Bisquaternary Drug Organochlorine
BW62C47	ACHE	Bisquaternary Trimethylammonium Ammonium
BW284C51	ACHE	Bisquaternary
Decamethonium	BCHE	Bisquaternary Trimethylammonium Ammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Decidium	ACHE	Bisquaternary Trimethylammonium Ammonium Phenanthridinium Derivative of Propidium
Hexamethonium	ACHE	Bisquaternary Nicotinic antagonist Trimethylammonium Ammonium
Mivacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Succinylcholine~Suxamethonium	BCHE	Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Ammonium Not AlphaBeta Hydrolase target
Doxacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium	BCHE	Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target