EJMC-12d
caffeic acid derivative 12d AChE IC50 = 3.72 +/- 0.34 microM; BChE IC50 = 9.65 +/- 0.08 microM
General
Type : Derivative of Tryptamine, Indole, Cinnamate, Hydroxycinnamic-ester, Antioxidant, Dihydroxyphenyl
Chemical_Nomenclature : N-{[N-2-(1H-indol-3-yl)ethylcarbamoyl]methyl}-(2E)-3-(3,4-dihydroxyphenyl)prop-2-enamide
Canonical SMILES : C1(=C(C=CC(=C1)C=CC(NCC(NCCC2=C[N]C3=CC=CC=C23)=O)=O)O)O
InChI : InChI=1S\/C21H21N3O4\/c25-18-7-5-14(11-19(18)26)6-8-20(27)24-13-21(28)22-10-9-15-12-23-17-4-2-1-3-16(15)17\/h1-8,11-12,23,25-26H,9-10,13H2,(H,22,28)(H,24,27)
InChIKey : RPSYWOAIXCNLHH-UHFFFAOYSA-N
Other name(s) : Compound 12d || N-{[N-2-(3-Indolyl)ethylcarbamoyl]methyl}-(E)-3-(3,4-dihydroxyphenyl)acrylamide
Target
References (3)
| Title : Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease - Kumar_2025_Eur.J.Med.Chem_296_117831 |
| Author(s) : Kumar S , Modi G |
| Ref : Eur Journal of Medicinal Chemistry , 296 :117831 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Eur.J.Med.Chem_296_117831 |
| PubMedID: 40578253 |
| Title : Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease - Kumar_2025_Eur.J.Med.Chem_296_117831 |
| Author(s) : Kumar S , Modi G |
| Ref : Eur Journal of Medicinal Chemistry , 296 :117831 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Eur.J.Med.Chem_296_117831 |
| PubMedID: 40578253 |
| Title : Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease - Kumar_2025_Eur.J.Med.Chem_296_117831 |
| Author(s) : Kumar S , Modi G |
| Ref : Eur Journal of Medicinal Chemistry , 296 :117831 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Eur.J.Med.Chem_296_117831 |
| PubMedID: 40578253 |