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Hydroxycinnamic-ester

General

Hydroxycinnamic acids (hydroxycinnamates) are a class of aromatic acids or phenylpropanoids having a C6-C3 skeleton Caffeic acid Cichoric acid Cinnamic acid Chlorogenic acid Coumaric acid Ferulic acid Sinapinic acid. Product of hydrolysis and inhibitor of some a/b hydrolases
Inhibitor Main targeted enzyme families Type Structure
KS07 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Cinnamate Acrylate
KS12 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Sinapyl Cinnamate Acrylate
EJMC-12d Derivative of Tryptamine Indole Cinnamate Hydroxycinnamic-ester Antioxidant Dihydroxyphenyl
Cinnamic-acid-N-benzyl-pyridinium-Cpd7b ACHE BCHE Hydroxycinnamic-ester Pyridine Pyridinium Derivative of Donepezil Cinnamate
Nlrp3-IN-33-Cpd12o ACHE BCHE Acrylate Feruloyl Quinoline Hydroxycinnamic-ester Multitarget Cinnamate NLRP3 inflammasome activation
Tacrine-cinnamic-hybrid-cpd10g ACHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Hydroxycinnamic-ester Alkyl linked bis-ligand Cinnamate
CHEMBL4533477 ACHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nitrobenzyl Cinnamate
CHEMBL4534662 ACHE BCHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Cinnamate Alkyl linked bis-ligand
Verbascoside S9N_PPCE_Peptidase_S9 Pancreatic_lipase Natural Hydroxycinnamic-ester Cinnamate Alkaloid Glycoside Dihydroxyphenyl Antioxidant
CHEMBL3393736 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget Hydroxycinnamic-ester Antioxidant Cinnamate Dihydroxyphenyl Organochlorine
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor Cinnamate
Caffeic-acid-phenethyl-ester BCHE ACHE Canar_LipB Hydroxycinnamic-ester Acrylate Not AlphaBeta Hydrolase target Natural Dihydroxyphenyl Cinnamate
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil Organochlorine Cinnamate
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Acridine Hydroxycinnamic-ester Cinnamate Alkyl linked bis-ligand
Rosmarinic-acid AlphaBeta_hydrolase Cholesterol_esterase Natural Hydroxycinnamic-ester Dihydroxyphenyl Cinnamate
Chlorogenic-acid Monoglyceridelipase_lysophospholip Natural Antioxidant Dihydroxyphenyl Cinnamate Hydroxycinnamic-ester
Caffeic-acid FAE-Bacterial-promiscuous Hydroxycinnamic-ester Cinnamate Acrylate Antioxidant Dihydroxyphenyl
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Acridine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nrf2 modulator Cinnamate