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Cinnamate

General

Cinnamic acid is a central intermediate in the biosynthesis of a myriad of natural products including lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and phenylpropanoids.
Inhibitor Main targeted enzyme families Type Structure
KS07 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Cinnamate Acrylate
KS12 ACHE Multitarget Piperidine Dimethoxyphenyl Benzylpiperidine Derivative of Donepezil Hydroxycinnamic-ester Sinapyl Cinnamate Acrylate
EJMC-12d Derivative of Tryptamine Indole Cinnamate Hydroxycinnamic-ester Antioxidant Dihydroxyphenyl
1-Caffeoylquinic-acid BCHE ACHE Natural Antioxidant Dihydroxyphenyl Cinnamate
Cinnamyl-acetate Canar_LipB Pancreatic_lipase Bacterial_lip_FamI.2 Fungal_carboxylesterase_lipase Lipase_2 Cinnamate Product-like inhibitor Acetate
Methylquinolin-amino-butyl-cinnamamide-Cpd14 Quinoline Cinnamate
Cinnamic-acid-N-benzyl-pyridinium-Cpd7b ACHE BCHE Hydroxycinnamic-ester Pyridine Pyridinium Derivative of Donepezil Cinnamate
Nlrp3-IN-33-Cpd12o ACHE BCHE Acrylate Feruloyl Quinoline Hydroxycinnamic-ester Multitarget Cinnamate NLRP3 inflammasome activation
Tacrine-cinnamic-hybrid-cpd10g ACHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Hydroxycinnamic-ester Alkyl linked bis-ligand Cinnamate
CHEMBL4533477 ACHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nitrobenzyl Cinnamate
CHEMBL4534662 ACHE BCHE Derivative of Tacrine Acridine Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Cinnamate Alkyl linked bis-ligand
Verbascoside S9N_PPCE_Peptidase_S9 Pancreatic_lipase Natural Hydroxycinnamic-ester Cinnamate Alkaloid Glycoside Dihydroxyphenyl Antioxidant
CHEMBL3393736 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget Hydroxycinnamic-ester Antioxidant Cinnamate Dihydroxyphenyl Organochlorine
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor Cinnamate
Caffeic-acid-phenethyl-ester BCHE ACHE Canar_LipB Hydroxycinnamic-ester Acrylate Not AlphaBeta Hydrolase target Natural Dihydroxyphenyl Cinnamate
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Benzylpiperidine Derivative of Donepezil Organochlorine Cinnamate
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Acridine Hydroxycinnamic-ester Cinnamate Alkyl linked bis-ligand
Rosmarinic-acid AlphaBeta_hydrolase Cholesterol_esterase Natural Hydroxycinnamic-ester Dihydroxyphenyl Cinnamate
Chlorogenic-acid Monoglyceridelipase_lysophospholip Natural Antioxidant Dihydroxyphenyl Cinnamate Hydroxycinnamic-ester
Caffeic-acid FAE-Bacterial-promiscuous Hydroxycinnamic-ester Cinnamate Acrylate Antioxidant Dihydroxyphenyl
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Acridine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand Nrf2 modulator Cinnamate
Cinnamoylphosphoramide ACHE Organophosphate Cinnamate Natural
Coumarin Coumarin Chromen Cinnamate