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Derivative of Tryptamine

General

Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. An indole: fused benzene and pyrrole ring, and a 2-aminoethyl group at the third carbon. The structure of tryptamine is a shared feature of certain aminergic neuromodulators including melatonin, serotonin (5-hydroxytryptamine 5-HT), bufotenin and psychedelic derivatives such as dimethyltryptamine (DMT), psilocybin, psilocin. Poor inhibitor of cholinesterase but active onaryl acylamidase AChE activity. Building block of some multitarget compounds
Inhibitor Main targeted enzyme families Type Structure
Melatonin-alkylbenzylamine-Cpd5 BCHE Antioxidant Derivative of Tryptamine Indole Multitarget Alkyl linked bis-ligand
6H6-Heptyl-Carbamate BCHE Carbamate Derivative of Tryptamine Indole
H327 BCHE Carbamate Derivative of Tryptamine Indole
BChE-IN-3 BCHE Derivative of Tryptophan Indole Carbamate Cycloheptyl Derivative of Tryptamine
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tryptamine ACHE Derivative of Tryptamine Indole Natural
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target
N-acetylserotonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
Melatonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural Antioxidant
Benzyl-2-triazole-linked-tryptamine-paeonol-Cpd896 BCHE Triazol Trifluoro Derivative of Tryptamine Indole
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Tacrine-Melatonin-Feruloyl-5c BCHE ACHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
5-hydroxy-tryptamine ACHE BCHE Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural 5-HT-receptor-ligand