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EMP-TMB4

Reactivators of organophosphate-inhibited ChEs give rise to phosphorylated oximes that reinhibit the enzyme. Reactivation of AChE inhibited by MEPQ with TMB4 will give EMP-TMB4

General

Type : Organophosphate, Phosphonylated oxime

Chemical_Nomenclature : ethoxyl methylphosphonyl-TMB4

Canonical SMILES : C1=[N+](C=CC(=C1)C(=NO)[H])CCC[N+]2=CC=C(C=C2)C(=NC[P](C)(OCC)=O)[H]

InChI : InChI=1S\/C19H26N4O3P\/c1-3-26-27(2,25)17-20-15-18-5-11-22(12-6-18)9-4-10-23-13-7-19(8-14-23)16-21-24\/h5-8,11-16H,3-4,9-10,17H2,1-2H3\/q+1\/p+1

InChIKey : DDIUMVSLOCHNNG-UHFFFAOYSA-O

Other name(s) : ethoxy methyl phosphonyl TMB-4  ||  EMP-Trimedoxime

MW : 461.32

Formula : C19H27Cl2N403P

CAS_number :

PubChem :

UniChem : DDIUMVSLOCHNNG-UHFFFAOYSA-O

Target

Families : EMP-TMB4 ligand of proteins in family
ACHE

References (1)

Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937
Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP
Ref : Biochemistry , 38 :9937 , 1999
Abstract :
PubMedSearch : Luo_1999_Biochemistry_38_9937
PubMedID: 10433700