Emodin
Emodin is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs. It has a role as a tyrosine kinase inhibitor, an antineoplastic agent, a laxative and a plant metabolite. Not strong inhibitor of ACHE: AChE 53.16 +/- 4.39 percent inhibition at concentrtation of 100 microg/mL. IC50 = 18.37 microg/ml. DPP4 IC50 of 5.76 microM
General
Type : Natural, Pyridine, Acridine, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : 1,3,8-trihydroxy-6-methylanthracene-9,10-dione
Canonical SMILES : CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O
InChI : InChI=1S\/C15H10O5\/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18\/h2-5,16-18H,1H3
InChIKey : RHMXXJGYXNZAPX-UHFFFAOYSA-N
Other name(s) : Aloe-emodin || Emodol || Frangula emodin || Schuttgelb || CHEMBL289277 || SCHEMBL177689
MW : 270.24
Formula : C15H10O5
CAS_number : 518-82-1
PubChem : 3220
UniChem : RHMXXJGYXNZAPX-UHFFFAOYSA-N
Target
References (8)
| Title : Insecticidal and Bactericidal Activities of Cassia nigricans Vahl and Molecular Docking Analysis of Insect Acetylcholinesterase - Fadimatou_2025_Turk.J.Pharm.Sci_21_520 |
| Author(s) : Fadimatou A , Boukli Hacene F , Ghalem M , Noumi GB , Momeni J , Mbaidanem LN , Ghalem S |
| Ref : Turk J Pharm Sci , 21 :520 , 2025 |
| Abstract : |
| PubMedSearch : Fadimatou_2025_Turk.J.Pharm.Sci_21_520 |
| PubMedID: 39801037 |
| Title : Emodin derivatives as novel potent DPP-4 inhibitors: Design, synthesis, and in vitro evaluation - Masyita_2024_Biochem.Biophys.Res.Commun_735_150867 |
| Author(s) : Masyita A , Firdayani F , Listiana S , Besari AY |
| Ref : Biochemical & Biophysical Research Communications , 735 :150867 , 2024 |
| Abstract : |
| PubMedSearch : Masyita_2024_Biochem.Biophys.Res.Commun_735_150867 |
| PubMedID: 39442451 |
| Title : Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors - Chinnasamy_2023_Environ.Sci.Pollut.Res.Int__ |
| Author(s) : Chinnasamy R , Govindasamy B , Venkatesh M , Magudeeswaran S , Dhanarajan A , Devarajan N , Willie P , Perumal V , Mekchay S , Krutmuang P |
| Ref : Environ Sci Pollut Res Int , : , 2023 |
| Abstract : |
| PubMedSearch : Chinnasamy_2023_Environ.Sci.Pollut.Res.Int__ |
| PubMedID: 36934179 |
| Title : Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking\/dynamics simulation, bioactivities evaluation, and cytoprotection - Shen_2023_Mol.Divers__2 |
| Author(s) : Shen R , Zhao W , Li X , Liu J , Yang A , Kou X |
| Ref : Mol Divers , : , 2023 |
| Abstract : |
| PubMedSearch : Shen_2023_Mol.Divers__2 |
| PubMedID: 37737959 |
| Title : Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4 - Wang_2017_PeerJ_5_e3283 |
| Author(s) : Wang Z , Yang L , Fan H , Wu P , Zhang F , Zhang C , Liu W , Li M |
| Ref : PeerJ , 5 :e3283 , 2017 |
| Abstract : |
| PubMedSearch : Wang_2017_PeerJ_5_e3283 |
| PubMedID: 28507818 |
| Title : Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and HO-induced cytotoxicity in PC12 cells - Tao_2014_Bioorg.Med.Chem.Lett_24_5385 |
| Author(s) : Tao L , Xie J , Wang Y , Wang S , Wu S , Wang Q , Ding H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 24 :5385 , 2014 |
| Abstract : |
| PubMedSearch : Tao_2014_Bioorg.Med.Chem.Lett_24_5385 |
| PubMedID: 25453793 |
| Title : Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors - Shi_2013_Bioorg.Med.Chem_21_1064 |
| Author(s) : Shi DH , Huang W , Li C , Wang LT , Wang SF |
| Ref : Bioorganic & Medicinal Chemistry , 21 :1064 , 2013 |
| Abstract : |
| PubMedSearch : Shi_2013_Bioorg.Med.Chem_21_1064 |
| PubMedID: 23380475 |
| Title : Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein - Vargas_2002_Pharmazie_57_399 |
| Author(s) : Vargas F , Fraile G , Velasquez M , Correia H , Fonseca G , Marin M , Marcano E , Sanchez Y |
| Ref : Pharmazie , 57 :399 , 2002 |
| Abstract : |
| PubMedSearch : Vargas_2002_Pharmazie_57_399 |
| PubMedID: 12116877 |