FNDP
General
Type : PET probe, Carboxamide
Chemical_Nomenclature : N-(3,3-diphenylpropyl)-6-fluoropyridine-3-carboxamide
Canonical SMILES : C1=CC=C(C=C1)C(CCNC(=O)C2=CN=C(C=C2)F)C3=CC=CC=C3
InChI : InChI=1S\/C21H19FN2O\/c22-20-12-11-18(15-24-20)21(25)23-14-13-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17\/h1-12,15,19H,13-14H2,(H,23,25)
InChIKey : CEPSBUIWVLQEKQ-UHFFFAOYSA-N
Other name(s) : 18F-Fndp || Fndp F-18 || (18F)-Fndp || U9F5EAB13Q || 18F-JHU-12315 || 6S9G3QJG4J || JHU-12315 || UNII-6S9G3QJG4J || 3-Pyridinecarboxamide, N-(3,3-diphenylpropyl)-6-fluoro || SCHEMBL4618267 || CHEMBL5222244 || CHEMBL5191424
Target
Families : FNDP ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (5)
| Title : [(18)F]FNDP PET neuroimaging test-retest repeatability and whole-body dosimetry in humans - Du_2023_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : Du Y , Coughlin JM , Amindarolzarbi A , Sweeney SE , Harrington CK , Brosnan MK , Zandi A , Shinehouse LK , Sanchez ANR , Abdallah R , Holt DP , Fan H , Lesniak WG , Nandi A , Rowe SP , Solnes LB , Dannals RF , Horti AG , Lodge MA , Pomper MG |
| Ref : Eur J Nucl Med Mol Imaging , : , 2023 |
| Abstract : |
| PubMedSearch : Du_2023_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 37458759 |
| Title : First-in-human neuroimaging of soluble epoxide hydrolase using [(18)F]FNDP PET - Coughlin_2021_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : Coughlin JM , Slania S , Du Y , Shinehouse LK , Brosnan MK , Azad BB , Holt DP , Fan H , Lesniak WG , Minn I , Rowe SP , Dannals RF , Horti AG , Pomper MG |
| Ref : Eur J Nucl Med Mol Imaging , : , 2021 |
| Abstract : |
| PubMedSearch : Coughlin_2021_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 33585963 |
| Title : PET imaging of soluble epoxide hydrolase in non-human primate brain with [(18)F]FNDP - Du_2020_EJNMMI.Res_10_67 |
| Author(s) : Du Y , Minn I , Foss C , Lesniak WG , Hu F , Dannals RF , Pomper MG , Horti AG |
| Ref : EJNMMI Res , 10 :67 , 2020 |
| Abstract : |
| PubMedSearch : Du_2020_EJNMMI.Res_10_67 |
| PubMedID: 32572592 |
| Title : An optimized radiosynthesis of [(18) F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH) - Azad_2018_J.Labelled.Comp.Radiopharm_61_567 |
| Author(s) : Azad BB , Holt DP , Ravert HT , Horti AG , Dannals RF |
| Ref : J Labelled Comp Radiopharm , 61 :567 , 2018 |
| Abstract : |
| PubMedSearch : Azad_2018_J.Labelled.Comp.Radiopharm_61_567 |
| PubMedID: 29529708 |
| Title : 18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase - Horti_2016_J.Nucl.Med_57_1817 |
| Author(s) : Horti AG , Wang Y , Minn I , Lan X , Wang J , Koehler RC , Alkayed NJ , Dannals RF , Pomper MG |
| Ref : J Nucl Med , 57 :1817 , 2016 |
| Abstract : |
| PubMedSearch : Horti_2016_J.Nucl.Med_57_1817 |
| PubMedID: 27417650 |