HDSF
PPT1 is insensitive to inactivation by PMSF or DFP, the enzyme is covalently modified and inactivated by hexadecylsulfonyl fluoride (HDSF). The active site do not accommodate an aromatic sulfonyl fluoride.
General
Type : Sulfur Compound, Sulfonyl
Chemical_Nomenclature : hexadecane-1-sulfonyl fluoride
Canonical SMILES : CCCCCCCCCCCCCCCCS(=O)(=O)F
InChI : InChI=1S\/C16H33FO2S\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19\/h2-16H2,1H3
InChIKey : QIVFMUVBIHIZAM-UHFFFAOYSA-N
Other name(s) : Hexadecylsulfonyl fluoride || Hexadecanesulfonyl fluoride || CHEMBL94809 || CHEBI:43275
MW : 308.49
Formula : C16H33FO2S
CAS_number : 86855-26-7
PubChem : 3572
UniChem : QIVFMUVBIHIZAM-UHFFFAOYSA-N
Target
Families : HDSF ligand of proteins in family
Palmitoyl-protein_thioesterase
Structure :
1EXW
Protein :
bovin-ppt
References (1)
| Title : Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride - Das_2000_J.Biol.Chem_275_23847 |
| Author(s) : Das AK , Bellizzi JJ, 3rd , Tandel S , Biehl E , Clardy J , Hofmann SL |
| Ref : Journal of Biological Chemistry , 275 :23847 , 2000 |
| Abstract : |
| PubMedSearch : Das_2000_J.Biol.Chem_275_23847 |
| PubMedID: 10801859 |
| Gene_locus related to this paper: bovin-ppt2 , human-PPT1 |