Savinainen JR

References (24)

Title : Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid alpha\/beta-Hydrolase Domain 6 (ABHD6) - Mardon_2022_J.Med.Chem__
Author(s) : Mardon K , Patel JZ , Savinainen JR , Stimson DHR , Oyagawa CRM , Grimsey NL , Migotto MA , Njiru GFM , Hamilton BR , Cowin G , Yli-Kauhaluoma J , Vanduffel W , Blakey I , Bhalla R , Cawthorne C , Celen S , Bormans G , Thurecht KJ , Ahamed M
Ref : Journal of Medicinal Chemistry , : , 2022
PubMedID: 36516997

Title : Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine - Della Pietra_2021_Int.J.Mol.Sci_22_
Author(s) : Della Pietra A , Giniatullin R , Savinainen JR
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33530477

Title : Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A - Ahonen_2018_ACS.Med.Chem.Lett_9_1269
Author(s) : Ahonen TJ , Savinainen JR , Yli-Kauhaluoma J , Kalso E , Laitinen JT , Moreira VM
Ref : ACS Med Chem Lett , 9 :1269 , 2018
PubMedID: 30613338
Gene_locus related to this paper: human-ABHD16A

Title : Synthesis and preclinical evaluation of [(11)C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL) - Ahamed_2017_Eur.J.Med.Chem_136_104
Author(s) : Ahamed M , Attili B , van Veghel D , Ooms M , Berben P , Celen S , Koole M , Declercq L , Savinainen JR , Laitinen JT , Verbruggen A , Bormans G
Ref : Eur Journal of Medicinal Chemistry , 136 :104 , 2017
PubMedID: 28486208

Title : A Sensitive and Versatile Fluorescent Activity Assay for ABHD6 - Savinainen_2016_Methods.Mol.Biol_1412_169
Author(s) : Savinainen JR , Navia-Paldanius D , Laitinen JT
Ref : Methods Mol Biol , 1412 :169 , 2016
PubMedID: 27245903

Title : A Sensitive and Versatile Fluorescent Activity Assay for ABHD12 - Savinainen_2016_Methods.Mol.Biol_1412_179
Author(s) : Savinainen JR , Navia-Paldanius D , Laitinen JT
Ref : Methods Mol Biol , 1412 :179 , 2016
PubMedID: 27245904

Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253
Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR
Ref : Eur J Pharm Sci , 93 :253 , 2016
PubMedID: 27544863
Gene_locus related to this paper: human-ABHD11

Title : In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)m ethanone (JJKK-048) - Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62
Author(s) : Aaltonen N , Kedzierska E , Orzelska-Gorka J , Lehtonen M , Navia-Paldanius D , Jakupovic H , Savinainen JR , Nevalainen T , Laitinen JT , Parkkari T , Gynther M
Ref : Journal of Pharmacology & Experimental Therapeutics , 359 :62 , 2016
PubMedID: 27451409

Title : Loratadine analogues as MAGL inhibitors - Patel_2015_Bioorg.Med.Chem.Lett_25_1436
Author(s) : Patel JZ , Ahenkorah S , Vaara M , Staszewski M , Adams Y , Laitinen T , Navia-Paldanius D , Parkkari T , Savinainen JR , Walczynski K , Laitinen JT , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1436 , 2015
PubMedID: 25752982

Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253
Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T
Ref : ChemMedChem , 10 :253 , 2015
PubMedID: 25504894
Gene_locus related to this paper: human-ABHD6

Title : Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi\/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase - Navia-Paldanius_2015_Eur.J.Pharm.Sci_77_180
Author(s) : Navia-Paldanius D , Aaltonen N , Lehtonen M , Savinainen JR , Taschler U , Radner FP , Zimmermann R , Laitinen JT
Ref : Eur J Pharm Sci , 77 :180 , 2015
PubMedID: 26070239

Title : Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors - Patel_2015_Bioorg.Med.Chem_23_6335
Author(s) : Patel JZ , van Bruchem J , Laitinen T , Kaczor AA , Navia-Paldanius D , Parkkari T , Savinainen JR , Laitinen JT , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry , 23 :6335 , 2015
PubMedID: 26344596

Title : Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency - Laitinen_2014_Mol.Pharmacol_85_510
Author(s) : Laitinen T , Navia-Paldanius D , Rytilahti R , Marjamaa JJ , Karizkova J , Parkkari T , Pantsar T , Poso A , Laitinen JT , Savinainen JR
Ref : Molecular Pharmacology , 85 :510 , 2014
PubMedID: 24368842
Gene_locus related to this paper: human-MGLL

Title : Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) - Korhonen_2014_Bioorg.Med.Chem_22_6694
Author(s) : Korhonen J , Kuusisto A , van Bruchem J , Patel JZ , Laitinen T , Navia-Paldanius D , Laitinen JT , Savinainen JR , Parkkari T , Nevalainen TJ
Ref : Bioorganic & Medicinal Chemistry , 22 :6694 , 2014
PubMedID: 25282655

Title : Discovery of Triterpenoids as Reversible Inhibitors of alpha\/beta-hydrolase Domain Containing 12 (ABHD12) - Parkkari_2014_PLoS.One_9_e98286
Author(s) : Parkkari T , Haavikko R , Laitinen T , Navia-Paldanius D , Rytilahti R , Vaara M , Lehtonen M , Alakurtti S , Yli-Kauhaluoma J , Nevalainen T , Savinainen JR , Laitinen JT
Ref : PLoS ONE , 9 :e98286 , 2014
PubMedID: 24879289
Gene_locus related to this paper: human-ABHD12

Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869
Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT
Ref : PLoS ONE , 9 :e109869 , 2014
PubMedID: 25290914
Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a

Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522
Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT
Ref : Molecular Pharmacology , 86 :522 , 2014
PubMedID: 25140003
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice - Aaltonen_2014_Eur.J.Pharm.Sci_51_87
Author(s) : Aaltonen N , Riera Ribas C , Lehtonen M , Savinainen JR , Laitinen JT
Ref : Eur J Pharm Sci , 51 :87 , 2014
PubMedID: 24012970

Title : Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase - Aaltonen_2013_Chem.Biol_20_379
Author(s) : Aaltonen N , Savinainen JR , Ribas CR , Ronkko J , Kuusisto A , Korhonen J , Navia-Paldanius D , Hayrinen J , Takabe P , Kasnanen H , Pantsar T , Laitinen T , Lehtonen M , Pasonen-Seppanen S , Poso A , Nevalainen T , Laitinen JT
Ref : Chemical Biology , 20 :379 , 2013
PubMedID: 23521796
Gene_locus related to this paper: human-MGLL

Title : Biochemical and pharmacological characterization of human alpha\/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) - Navia-Paldanius_2012_J.Lipid.Res_53_2413
Author(s) : Navia-Paldanius D , Savinainen JR , Laitinen JT
Ref : J Lipid Res , 53 :2413 , 2012
PubMedID: 22969151
Gene_locus related to this paper: human-ABHD6 , human-ABHD12

Title : The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors - Savinainen_2012_Acta.Physiol.(Oxf)_204_267
Author(s) : Savinainen JR , Saario SM , Laitinen JT
Ref : Acta Physiol (Oxf) , 204 :267 , 2012
PubMedID: 21418147
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL

Title : Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique - Savinainen_2010_Anal.Biochem_399_132
Author(s) : Savinainen JR , Yoshino M , Minkkila A , Nevalainen T , Laitinen JT
Ref : Analytical Biochemistry , 399 :132 , 2010
PubMedID: 20005861
Gene_locus related to this paper: human-MGLL

Title : Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors -
Author(s) : Minkkila A , Savinainen JR , Kasnanen H , Xhaard H , Nevalainen T , Laitinen JT , Poso A , Leppanen J , Saario SM
Ref : ChemMedChem , 4 :1253 , 2009
PubMedID: 19472270

Title : Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes - Saario_2004_Biochem.Pharmacol_67_1381
Author(s) : Saario SM , Savinainen JR , Laitinen JT , Jarvinen T , Niemi R
Ref : Biochemical Pharmacology , 67 :1381 , 2004
PubMedID: 15013854