| Title : Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A - Ahonen_2018_ACS.Med.Chem.Lett_9_1269 |
| Author(s) : Ahonen TJ , Savinainen JR , Yli-Kauhaluoma J , Kalso E , Laitinen JT , Moreira VM |
| Ref : ACS Med Chem Lett , 9 :1269 , 2018 |
| Abstract : |
| PubMedSearch : Ahonen_2018_ACS.Med.Chem.Lett_9_1269 |
| PubMedID: 30613338 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : Synthesis and preclinical evaluation of [(11)C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL) - Ahamed_2017_Eur.J.Med.Chem_136_104 |
| Author(s) : Ahamed M , Attili B , van Veghel D , Ooms M , Berben P , Celen S , Koole M , Declercq L , Savinainen JR , Laitinen JT , Verbruggen A , Bormans G |
| Ref : Eur Journal of Medicinal Chemistry , 136 :104 , 2017 |
| Abstract : |
| PubMedSearch : Ahamed_2017_Eur.J.Med.Chem_136_104 |
| PubMedID: 28486208 |
| Title : A Sensitive and Versatile Fluorescent Activity Assay for ABHD6 - Savinainen_2016_Methods.Mol.Biol_1412_169 |
| Author(s) : Savinainen JR , Navia-Paldanius D , Laitinen JT |
| Ref : Methods Mol Biol , 1412 :169 , 2016 |
| Abstract : |
| PubMedSearch : Savinainen_2016_Methods.Mol.Biol_1412_169 |
| PubMedID: 27245903 |
| Title : A Sensitive and Versatile Fluorescent Activity Assay for ABHD12 - Savinainen_2016_Methods.Mol.Biol_1412_179 |
| Author(s) : Savinainen JR , Navia-Paldanius D , Laitinen JT |
| Ref : Methods Mol Biol , 1412 :179 , 2016 |
| Abstract : |
| PubMedSearch : Savinainen_2016_Methods.Mol.Biol_1412_179 |
| PubMedID: 27245904 |
| Title : In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)m ethanone (JJKK-048) - Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| Author(s) : Aaltonen N , Kedzierska E , Orzelska-Gorka J , Lehtonen M , Navia-Paldanius D , Jakupovic H , Savinainen JR , Nevalainen T , Laitinen JT , Parkkari T , Gynther M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 359 :62 , 2016 |
| Abstract : |
| PubMedSearch : Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| PubMedID: 27451409 |
| Title : Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha\/beta-hydrolase domain containing 11 (ABHD11) - Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| Author(s) : Navia-Paldanius D , Patel JZ , Lopez Navarro M , Jakupovic H , Goffart S , Pasonen-Seppanen S , Nevalainen TJ , Jaaskelainen T , Laitinen T , Laitinen JT , Savinainen JR |
| Ref : Eur J Pharm Sci , 93 :253 , 2016 |
| Abstract : |
| PubMedSearch : Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253 |
| PubMedID: 27544863 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors - Patel_2015_ChemMedChem_10_253 |
| Author(s) : Patel JZ , Nevalainen TJ , Savinainen JR , Adams Y , Laitinen T , Runyon RS , Vaara M , Ahenkorah S , Kaczor AA , Navia-Paldanius D , Gynther M , Aaltonen N , Joharapurkar AA , Jain MR , Haka AS , Maxfield FR , Laitinen JT , Parkkari T |
| Ref : ChemMedChem , 10 :253 , 2015 |
| Abstract : |
| PubMedSearch : Patel_2015_ChemMedChem_10_253 |
| PubMedID: 25504894 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Loratadine analogues as MAGL inhibitors - Patel_2015_Bioorg.Med.Chem.Lett_25_1436 |
| Author(s) : Patel JZ , Ahenkorah S , Vaara M , Staszewski M , Adams Y , Laitinen T , Navia-Paldanius D , Parkkari T , Savinainen JR , Walczynski K , Laitinen JT , Nevalainen TJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1436 , 2015 |
| Abstract : |
| PubMedSearch : Patel_2015_Bioorg.Med.Chem.Lett_25_1436 |
| PubMedID: 25752982 |
| Title : Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors - Patel_2015_Bioorg.Med.Chem_23_6335 |
| Author(s) : Patel JZ , van Bruchem J , Laitinen T , Kaczor AA , Navia-Paldanius D , Parkkari T , Savinainen JR , Laitinen JT , Nevalainen TJ |
| Ref : Bioorganic & Medicinal Chemistry , 23 :6335 , 2015 |
| Abstract : |
| PubMedSearch : Patel_2015_Bioorg.Med.Chem_23_6335 |
| PubMedID: 26344596 |
| Title : Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi\/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase - Navia-Paldanius_2015_Eur.J.Pharm.Sci_77_180 |
| Author(s) : Navia-Paldanius D , Aaltonen N , Lehtonen M , Savinainen JR , Taschler U , Radner FP , Zimmermann R , Laitinen JT |
| Ref : Eur J Pharm Sci , 77 :180 , 2015 |
| Abstract : |
| PubMedSearch : Navia-Paldanius_2015_Eur.J.Pharm.Sci_77_180 |
| PubMedID: 26070239 |
| Title : Discovery of Triterpenoids as Reversible Inhibitors of alpha\/beta-hydrolase Domain Containing 12 (ABHD12) - Parkkari_2014_PLoS.One_9_e98286 |
| Author(s) : Parkkari T , Haavikko R , Laitinen T , Navia-Paldanius D , Rytilahti R , Vaara M , Lehtonen M , Alakurtti S , Yli-Kauhaluoma J , Nevalainen T , Savinainen JR , Laitinen JT |
| Ref : PLoS ONE , 9 :e98286 , 2014 |
| Abstract : |
| PubMedSearch : Parkkari_2014_PLoS.One_9_e98286 |
| PubMedID: 24879289 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) - Korhonen_2014_Bioorg.Med.Chem_22_6694 |
| Author(s) : Korhonen J , Kuusisto A , van Bruchem J , Patel JZ , Laitinen T , Navia-Paldanius D , Laitinen JT , Savinainen JR , Parkkari T , Nevalainen TJ |
| Ref : Bioorganic & Medicinal Chemistry , 22 :6694 , 2014 |
| Abstract : |
| PubMedSearch : Korhonen_2014_Bioorg.Med.Chem_22_6694 |
| PubMedID: 25282655 |
| Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522 |
| Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT |
| Ref : Molecular Pharmacology , 86 :522 , 2014 |
| Abstract : |
| PubMedSearch : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedID: 25140003 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869 |
| Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT |
| Ref : PLoS ONE , 9 :e109869 , 2014 |
| Abstract : |
| PubMedSearch : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedID: 25290914 |
| Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a |
| Title : Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency - Laitinen_2014_Mol.Pharmacol_85_510 |
| Author(s) : Laitinen T , Navia-Paldanius D , Rytilahti R , Marjamaa JJ , Karizkova J , Parkkari T , Pantsar T , Poso A , Laitinen JT , Savinainen JR |
| Ref : Molecular Pharmacology , 85 :510 , 2014 |
| Abstract : |
| PubMedSearch : Laitinen_2014_Mol.Pharmacol_85_510 |
| PubMedID: 24368842 |
| Gene_locus related to this paper: human-MGLL |
| Title : Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice - Aaltonen_2014_Eur.J.Pharm.Sci_51_87 |
| Author(s) : Aaltonen N , Riera Ribas C , Lehtonen M , Savinainen JR , Laitinen JT |
| Ref : Eur J Pharm Sci , 51 :87 , 2014 |
| Abstract : |
| PubMedSearch : Aaltonen_2014_Eur.J.Pharm.Sci_51_87 |
| PubMedID: 24012970 |
| Title : Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase - Aaltonen_2013_Chem.Biol_20_379 |
| Author(s) : Aaltonen N , Savinainen JR , Ribas CR , Ronkko J , Kuusisto A , Korhonen J , Navia-Paldanius D , Hayrinen J , Takabe P , Kasnanen H , Pantsar T , Laitinen T , Lehtonen M , Pasonen-Seppanen S , Poso A , Nevalainen T , Laitinen JT |
| Ref : Chemical Biology , 20 :379 , 2013 |
| Abstract : |
| PubMedSearch : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedID: 23521796 |
| Gene_locus related to this paper: human-MGLL |
| Title : Biochemical and pharmacological characterization of human alpha\/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) - Navia-Paldanius_2012_J.Lipid.Res_53_2413 |
| Author(s) : Navia-Paldanius D , Savinainen JR , Laitinen JT |
| Ref : J Lipid Res , 53 :2413 , 2012 |
| Abstract : |
| PubMedSearch : Navia-Paldanius_2012_J.Lipid.Res_53_2413 |
| PubMedID: 22969151 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 |
| Title : The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors - Savinainen_2012_Acta.Physiol.(Oxf)_204_267 |
| Author(s) : Savinainen JR , Saario SM , Laitinen JT |
| Ref : Acta Physiol (Oxf) , 204 :267 , 2012 |
| Abstract : |
| PubMedSearch : Savinainen_2012_Acta.Physiol.(Oxf)_204_267 |
| PubMedID: 21418147 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique - Savinainen_2010_Anal.Biochem_399_132 |
| Author(s) : Savinainen JR , Yoshino M , Minkkila A , Nevalainen T , Laitinen JT |
| Ref : Analytical Biochemistry , 399 :132 , 2010 |
| Abstract : |
| PubMedSearch : Savinainen_2010_Anal.Biochem_399_132 |
| PubMedID: 20005861 |
| Gene_locus related to this paper: human-MGLL |
| Title : Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors - |
| Author(s) : Minkkila A , Savinainen JR , Kasnanen H , Xhaard H , Nevalainen T , Laitinen JT , Poso A , Leppanen J , Saario SM |
| Ref : ChemMedChem , 4 :1253 , 2009 |
| PubMedID: 19472270 |
| Title : Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors - Saario_2007_Basic.Clin.Pharmacol.Toxicol_101_287 |
| Author(s) : Saario SM , Laitinen JT |
| Ref : Basic Clin Pharmacol Toxicol , 101 :287 , 2007 |
| Abstract : |
| PubMedSearch : Saario_2007_Basic.Clin.Pharmacol.Toxicol_101_287 |
| PubMedID: 17910610 |
| Title : Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes - Saario_2005_Chem.Biol_12_649 |
| Author(s) : Saario SM , Salo OM , Nevalainen T , Poso A , Laitinen JT , Jarvinen T , Niemi R |
| Ref : Chemical Biology , 12 :649 , 2005 |
| Abstract : |
| PubMedSearch : Saario_2005_Chem.Biol_12_649 |
| PubMedID: 15975510 |
| Title : Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes - Saario_2004_Biochem.Pharmacol_67_1381 |
| Author(s) : Saario SM , Savinainen JR , Laitinen JT , Jarvinen T , Niemi R |
| Ref : Biochemical Pharmacology , 67 :1381 , 2004 |
| Abstract : |
| PubMedSearch : Saario_2004_Biochem.Pharmacol_67_1381 |
| PubMedID: 15013854 |
| Title : Cholinergic signaling in the rat pineal gland. - Laitinen_1995_Cell.Mol.Neurobiol_15_177 |
| Author(s) : Laitinen JT , Laitinen KS , Kokkola T |
| Ref : Cellular Molecular Neurobiology , 15 :177 , 1995 |
| Abstract : |
| PubMedSearch : Laitinen_1995_Cell.Mol.Neurobiol_15_177 |
| PubMedID: 8590450 |