HSL-IN-1
human HSL IC50 68nM
General
Type : Boron compound, Pyridine, Trifluoro
Chemical_Nomenclature : [5-chloro-2-[[6-[4-(trifluoromethyl)phenoxy]pyridine-3-carbonyl]amino]phenyl]boronic acid
Canonical SMILES : B(C1=C(C=CC(=C1)Cl)NC(=O)C2=CN=C(C=C2)OC3=CC=C(C=C3)C(F)(F)F)(O)O
InChI : InChI=1S\/C19H13BClF3N2O4\/c21-13-4-7-16(15(9-13)20(28)29)26-18(27)11-1-8-17(25-10-11)30-14-5-2-12(3-6-14)19(22,23)24\/h1-10,28-29H,(H,26,27)
InChIKey : PDMXSCCBEBCTGX-UHFFFAOYSA-N
Other name(s) : Compound 25a || CHEMBL4063082 || (5-Chloro-2-(6-(4-(trifluoromethyl)phenoxy)nicotinamido)phenyl)boronic acid || VID15613 || BDBM50233398 || AKOS040733391
MW : 436.6
Formula : C19H13BClF3N2O4
CAS_number : 2095156-13-9
PubChem : 132569642
UniChem : PDMXSCCBEBCTGX-UHFFFAOYSA-N
Target
Families : HSL-IN-1 ligand of proteins in family
Hormone-sensitive_lipase_like
Protein :
human-LIPE
References (3)
| Title : Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets - Peng_2025_Nat.Commun_16_3497 |
| Author(s) : Peng H , Xu Q , Zhang T , Zhu J , Pan J , Guan X , Feng S , Wu J , Hu Q |
| Ref : Nat Commun , 16 :3497 , 2025 |
| Abstract : |
| PubMedSearch : Peng_2025_Nat.Commun_16_3497 |
| PubMedID: 40221426 |
| Gene_locus related to this paper: human-LIPE |
| Title : Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor - Ogiyama_2017_Bioorg.Med.Chem_25_4817 |
| Author(s) : Ogiyama T , Yamaguchi M , Kurikawa N , Honzumi S , Terayama K , Nagaoka N , Yamamoto Y , Kimura T , Sugiyama D , Inoue SI |
| Ref : Bioorganic & Medicinal Chemistry , 25 :4817 , 2017 |
| Abstract : |
| PubMedSearch : Ogiyama_2017_Bioorg.Med.Chem_25_4817 |
| PubMedID: 28756012 |
| Gene_locus related to this paper: human-LIPE |
| Title : Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation - Ogiyama_2017_Bioorg.Med.Chem_25_2234 |
| Author(s) : Ogiyama T , Yamaguchi M , Kurikawa N , Honzumi S , Yamamoto Y , Sugiyama D , Takakusa H , Inoue SI |
| Ref : Bioorganic & Medicinal Chemistry , 25 :2234 , 2017 |
| Abstract : |
| PubMedSearch : Ogiyama_2017_Bioorg.Med.Chem_25_2234 |
| PubMedID: 28279560 |
| Gene_locus related to this paper: human-LIPE |