Juliflorine
from Prosopis juliflora IC50 = 0.42 microM AChE; IC50 = 0.12 microM BChE
General
Type : Indole, Alkaloid, Natural
Chemical_Nomenclature : 6-[10-[7-[10-(5-hydroxy-6-methylpiperidin-2-yl)decyl]-1,2,3,5,8,8a-hexahydroindolizin-8-yl]decyl]-2-methylpiperidin-3-ol
Canonical SMILES : CC1C(CCC(N1)CCCCCCCCCCC2C3CCCN3CC=C2CCCCCCCCCCC4CCC(C(N4)C)O)O
InChI : InChI=1S\/C40H75N3O2\/c1-32-39(44)27-25-35(41-32)21-16-12-8-4-3-7-11-15-20-34-29-31-43-30-19-24-38(43)37(34)23-18-14-10-6-5-9-13-17-22-36-26-28-40(45)33(2)42-36\/h29,32-33,35-42,44-45H,3-28,30-31H2,1-2H3
InChIKey : WJNGOLJEAOQNFW-UHFFFAOYSA-N
Other name(s) : DTXSID501033954 || RefChem:924000 || DTXCID401518692 || 3-Piperidinol, 6,6'-((1,2,3,5,8,8a-hexahydro-6,8-indolizinediyl)di-10,1-decanediyl)bis(2-methyl) || Juliflorine || Juliprosopin || BRN 4340614
Target
Families : Juliflorine ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (3)
| Title : Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy - Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| Author(s) : Choudhary MI , Nawaz SA , Zaheer ul H , Azim MK , Ghayur MN , Lodhi MA , Jalil S , Khalid A , Ahmed A , Rode BM , Atta ur R , Gilani AU , Ahmad VU |
| Ref : Biochemical & Biophysical Research Communications , 332 :1171 , 2005 |
| Abstract : |
| PubMedSearch : Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| PubMedID: 16021692 |
| Title : Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy - Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| Author(s) : Choudhary MI , Nawaz SA , Zaheer ul H , Azim MK , Ghayur MN , Lodhi MA , Jalil S , Khalid A , Ahmed A , Rode BM , Atta ur R , Gilani AU , Ahmad VU |
| Ref : Biochemical & Biophysical Research Communications , 332 :1171 , 2005 |
| Abstract : |
| PubMedSearch : Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| PubMedID: 16021692 |
| Title : Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy - Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| Author(s) : Choudhary MI , Nawaz SA , Zaheer ul H , Azim MK , Ghayur MN , Lodhi MA , Jalil S , Khalid A , Ahmed A , Rode BM , Atta ur R , Gilani AU , Ahmad VU |
| Ref : Biochemical & Biophysical Research Communications , 332 :1171 , 2005 |
| Abstract : |
| PubMedSearch : Choudhary_2005_Biochem.Biophys.Res.Commun_332_1171 |
| PubMedID: 16021692 |