KT182
General
Type : Piperidine, Triazol
Chemical_Nomenclature : [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone
Canonical SMILES : C1CCN(C(C1)C2=CC=CC=C2)C(=O)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC(=C5)CO
InChI : InChI=1S\/C27H26N4O2\/c32-19-20-7-6-10-24(17-20)21-12-14-22(15-13-21)25-18-31(29-28-25)27(33)30-16-5-4-11-26(30)23-8-2-1-3-9-23\/h1-3,6-10,12-15,17-18,26,32H,4-5,11,16,19H2
InChIKey : GICNKPZHUCVFNM-UHFFFAOYSA-N
Other name(s) : CHEMBL3263577 || (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone
MW : 438.5
Formula : C27H26N4O2
CAS_number : 1402612-62-7
PubChem : 53364491
UniChem : GICNKPZHUCVFNM-UHFFFAOYSA-N
Target
Families : KT182 ligand of proteins in family
ABHD6-Lip
Protein :
human-ABHD6
References (3)
| Title : Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis - Manterola_2018_Neuropharmacol_141_181 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Ruiz A , Perez-Samartin A , Moreno-Rodriguez M , Hsu KL , Cravatt BF , Brown JM , Rodriguez-Puertas R , Matute C , Mato S |
| Ref : Neuropharmacology , 141 :181 , 2018 |
| Abstract : |
| PubMedSearch : Manterola_2018_Neuropharmacol_141_181 |
| PubMedID: 30171986 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism - Tanaka_2017_J.Neuroinflammation_14_7 |
| Author(s) : Tanaka M , Moran S , Wen J , Affram K , Chen T , Symes AJ , Zhang Y |
| Ref : J Neuroinflammation , 14 :7 , 2017 |
| Abstract : |
| PubMedSearch : Tanaka_2017_J.Neuroinflammation_14_7 |
| PubMedID: 28086912 |
| Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270 |
| Author(s) : Hsu KL , Tsuboi K , Chang JW , Whitby LR , Speers AE , Pugh H , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8270 , 2013 |
| Abstract : |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8270 |
| PubMedID: 24152295 |