MAGL-IN-16
Compound 27 (IC(50) = 10.3 nM)
General
Type : Pyridine, Piperazine, Quinoline
Chemical_Nomenclature : 7-[4-[5-(4-chlorophenyl)-2-pyridinyl]piperazine-1-carbonyl]-1H-quinolin-2-one
Canonical SMILES : C1CN(CCN1C2=NC=C(C=C2)C3=CC=C(C=C3)Cl)C(=O)C4=CC5=C(C=C4)C=CC(=O)N5
InChI : InChI=1S\/C25H21ClN4O2\/c26-21-7-3-17(4-8-21)20-5-9-23(27-16-20)29-11-13-30(14-12-29)25(32)19-2-1-18-6-10-24(31)28-22(18)15-19\/h1-10,15-16H,11-14H2,(H,28,31)
InChIKey : PYHXAEHINZRSNN-UHFFFAOYSA-N
Other name(s) : CHEMBL5563162 || 7-[4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine-1-carbonyl]quinolin-2(1H)-one || 7-(4-(5-(4-Chlorophenyl) pyridin-2-yl) piperazine-1-carbonyl) quinolin-2(1H)-one || Compound 27 || SCHEMBL31605472
MW : 444.9
Formula : C25H21ClN4O2
CAS_number : 3085542-06-6
PubChem : 171038001
UniChem : PYHXAEHINZRSNN-UHFFFAOYSA-N
Target
Families : MAGL-IN-16 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression - Hao_2024_Eur.J.Med.Chem_268_116285 |
| Author(s) : Hao Q , Shi J , Zhang Z , Yang G , Zhi Y , Wang K , Ma D , Fu S , Dong H , Zhi Z , Zhang W , Li T , Wang J |
| Ref : Eur Journal of Medicinal Chemistry , 268 :116285 , 2024 |
| Abstract : |
| PubMedSearch : Hao_2024_Eur.J.Med.Chem_268_116285 |
| PubMedID: 38428273 |