MGLL-IN-Cpd34
pIC50 of 7.1 specific
General
Type : Piperazine, Naphthalen, Naphthylamide
Chemical_Nomenclature : cis-(2,3-Dimethyl-4-phenylpiperazin-1-yl)(naphthalen-1-yl)methanone
Canonical SMILES : C1=CC=CC(=C1)N2CCN(C(C2C)C)C(C3=CC=CC4=C3C=CC=C4)=O
InChI : InChI=1S\/C23H24N2O\/c1-17-18(2)25(16-15-24(17)20-11-4-3-5-12-20)23(26)22-14-8-10-19-9-6-7-13-21(19)22\/h3-14,17-18H,15-16H2,1-2H3
InChIKey : RBYJCRPFIXEPRQ-UHFFFAOYSA-N
Other name(s) : Compound +\/-34
Target
Families : MGLL-IN-Cpd34 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Design, synthesis and biological evaluation of naphthyl amide derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Yu_2024_Bioorg.Med.Chem_111_117844 |
| Author(s) : Yu Q , Song C , Bi L , Zhao S , Lei Q , Yang N , Chen H , Wang Y , He Y , Deng H |
| Ref : Bioorganic & Medicinal Chemistry , 111 :117844 , 2024 |
| Abstract : |
| PubMedSearch : Yu_2024_Bioorg.Med.Chem_111_117844 |
| PubMedID: 39106652 |