MR33317
5-HT4-receptor Ki 42.5 +/- 2.6 nM partial agonist with 35.6% of the activity of 10 M serotonin. ACHE IC50-value of 41 +/- 5 nM . 1 microM MR33317 inhibited the activity of acetylcholinesterase by 93%. MR33317 may lead to atrial fibrillation
General
Type : Multitarget, 5-HT-receptor-ligand, Piperidine
Chemical_Nomenclature : (1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-(3-methylbenzyl)piperidin-4-yl)propan-1-one)
Canonical SMILES : C1=C(C(=CC(=C1OC)C(CCC2CCN(CC2)CC3=CC(=CC=C3)N)=O)Cl)N
InChI : InChI=1S\/C22H28ClN3O2\/c1-28-22-13-20(25)19(23)12-18(22)21(27)6-5-15-7-9-26(10-8-15)14-16-3-2-4-17(24)11-16\/h2-4,11-13,15H,5-10,14,24-25H2,1H3
InChIKey : CSAFZBPIXXBPCQ-UHFFFAOYSA-N
Other name(s) :
Target
Families : MR33317 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Studies on the mechanisms of action of MR33317 - Neumann_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| Author(s) : Neumann J , Hesse C , Yahiaoui S , Dallemagne P , Rochais C , Hofmann B , Gergs U |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , : , 2024 |
| Abstract : |
| PubMedSearch : Neumann_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| PubMedID: 38856912 |