Mebbpp
IC50 6.8 nm +/-1.4 for human AChE and 3400+/-1406.nM for human BChE
General
Type : Derivative of Donepezil, Multitarget, Sulfur Compound, Piperidine
Chemical_Nomenclature : 3-(1-benzylpiperidin-4-yl)-1-(2-methyl-1,3-benzothiazol-6-yl)propan-1-one
Canonical SMILES : CC1=NC2=C(S1)C=C(C=C2)C(=O)CCC3CCN(CC3)CC4=CC=CC=C4
InChI : InChI=1S\/C23H26N2OSc1-17-24-21-9-8-20(15-23(21)27-17)22(26)10-7-18-11-13-25(14-12-18)16-19-5-3-2-4-6-19\;\/h2-6,8-9,15,18H,7,10-14,16H2,1H3\;1H
InChIKey : JCRRTHOBVNDWLU-UHFFFAOYSA-N
Other name(s) : UNII-HQ489718DL || 6d || HQ489718DL || CHEMBL542543
MW : 415
Formula : C23H26N2OS
CAS_number : 149292-56-8
PubChem : 192441
UniChem : JCRRTHOBVNDWLU-UHFFFAOYSA-N
Target
Families : Mebbpp ligand of proteins in family
ACHE
References (1)
| Title : Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors - Nagel_1995_J.Med.Chem_38_1084 |
| Author(s) : Nagel AA , Liston DR , Jung S , Mahar M , Vincent LA , Chapin D , Chen YL , Hubbard S , Ives JL , Jones SB , Nielsen JA , Ramirez A , Shalaby IA , Villalobos A , White WF |
| Ref : Journal of Medicinal Chemistry , 38 :1084 , 1995 |
| Abstract : |
| PubMedSearch : Nagel_1995_J.Med.Chem_38_1084 |
| PubMedID: 7707311 |