Methoxyphenylmethylpiperidin-thiophen-methyl-carbamoyl-methyl-amino-pyrimidine-carboxamide-Cpd17v
IC50 AChE 0.96 microM; IC50 BChE 7.12 microM
General
Type : Piperidine, Sulfur Compound, Thiophen, Pyrimidine, Carboxamide
Chemical_Nomenclature : N-{1-[(3-methoxyphenyl)methyl]piperidin-4-yl}-2-[({N-[(thiophen-2-yl)methyl]carbamoyl}methyl)amino]pyrimidine-5-carboxamide
Canonical SMILES : C1(=CC=CS1)CNC(CNC2=NC=C(C=N2)C(=O)NC3CCN(CC3)CC4=CC=CC(=C4)OC)=O
InChI : InChI=1S\/C25H30N6O3S\/c1-34-21-5-2-4-18(12-21)17-31-9-7-20(8-10-31)30-24(33)19-13-27-25(28-14-19)29-16-23(32)26-15-22-6-3-11-35-22\/h2-6,11-14,20H,7-10,15-17H2,1H3,(H,26,32)(H,30,33)(H,27,28,29)
InChIKey : XOBGNOODMVTBGL-UHFFFAOYSA-N
Other name(s) : N-{1-[(m-Methoxyphenyl)methyl]-4-piperidyl}-2-{[(N-thenylcarbamoyl)methyl]amino}-5-pyrimidinecarboxamide || Compound 17v
Target
Families : Methoxyphenylmethylpiperidin-thiophen-methyl-carbamoyl-methyl-amino-pyrimidine-carboxamide-Cpd17v ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis, biological activity and computational simulation evaluation of pyrimidine-2-aminoacetamide derivatives as cholinesterase inhibitors - Wang_2026_Med.Chem.Res__ |
| Author(s) : Wang YX , Qin SH , Liu Q , Zhou XW , Zhang CY , Ma ZY |
| Ref : Med Chem Res , : , 2026 |
| Abstract : |
| PubMedSearch : Wang_2026_Med.Chem.Res__ |
| PubMedID: 42627505 |