Morpholino-phenylthiazolidin-one-Cpd12
Morpholine-modified thiosemicarbazones and thiazolidin-4-one Ki nM AChE 32.83 +/- 4.45 ; BChE 37.07 +/- 9.21
General
Type : Thiazolidine, Thiazole, Sulfur Compound, Morpholine, Hydrazide
Chemical_Nomenclature : (E)-2-((4-Hydroxy-3,5-bis(morpholinomethyl)benzylidene)hydrazineylidene)-3-phenylthiazolidin-4-one
Canonical SMILES : S4C(=NN=CC2=CC(CN1CCOCC1)C(C(=C2)CN3CCOCC3)O)N(C(C4)=O)C5=CC=CC=C5
InChI : InChI=1S\/C26H33N5O4S\/c32-24-19-36-26(31(24)23-4-2-1-3-5-23)28-27-16-20-14-21(17-29-6-10-34-11-7-29)25(33)22(15-20)18-30-8-12-35-13-9-30\/h1-5,14-16,21,25,33H,6-13,17-19H2
InChIKey : VUMGLXGIHLEVTM-UHFFFAOYSA-N
Other name(s) : Compound 12
Target
Families : Morpholino-phenylthiazolidin-one-Cpd12 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Morpholine-modified thiosemicarbazones and thiazolidin-4-ones against Alzheimer's key enzymes: From synthesis to inhibition - Demir_2025_Comput.Biol.Chem_120_108683 |
| Author(s) : Demir Y , Senol H , Ulucay O , Atesoglu S S , Tokali FS |
| Ref : Comput Biol Chem , 120 :108683 , 2025 |
| Abstract : |
| PubMedSearch : Demir_2025_Comput.Biol.Chem_120_108683 |
| PubMedID: 40966959 |