Naphthyl-carbohydrazone-Cpd11
Ki 52.42 nM (hCA I); 59.23 nM (hCA II); and 40.16 nM AChE
General
Type : Multitarget, Carbonic anhydrase inhibitor, Urea derivative, Naphthalen, Indole, Hydrazide, Organochlorine
Chemical_Nomenclature : N-(5-chloro-2-oxoindolin-3-ylidene)-2-(naphthalen-1-ylmethylene)hydrazine-1-carbohydrazide
Canonical SMILES : C3(=N\/N(C(N(N=CC1=CC=CC2=C1C=CC=C2)[H])=O)[H])\/C4=C(N(C3=O)[H])C=CC(=C4)Cl
InChI : InChI=1S\/C20H14ClN5O2\/c21-14-8-9-17-16(10-14)18(19(27)23-17)24-26-20(28)25-22-11-13-6-3-5-12-4-1-2-7-15(12)13\/h1-11H,(H,23,24,27)(H2,25,26,28)
InChIKey : NYBIJEPQFIEUBM-UHFFFAOYSA-N
Other name(s) : compound 11
Target
Families : Naphthyl-carbohydrazone-Cpd11 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : A new series of naphthyl-thiosemicarbazone and thio\/carbohydrazone derivatives: Synthesis, spectroscopic elucidation, dual enzyme inhibition targeting carbonic anhydrase and acetylcholinesterase and molecular docking studies - Yakan_2025_Arch.Biochem.Biophys__110491 |
| Author(s) : Yakan H , Muglu H , Erdogan M , Turkes C , Demir Y |
| Ref : Archives of Biochemistry & Biophysics , :110491 , 2025 |
| Abstract : |
| PubMedSearch : Yakan_2025_Arch.Biochem.Biophys__110491 |
| PubMedID: 40451602 |