Octacosanol
Octacosan-1-ol is an ultra-long-chain primary fatty alcohol that is octacosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group. Cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties. pancreatic lipase inhibitory activity with an IC50 of 7.87 +/- 0.72 microg/mL (19 microM). OCT binds to pancreatic lipase with an affinity comparable to orlistat and stronger than that of 4-nitrophenyl palmitate
General
Type : Analogue of substrate, Product-like inhibitor, Natural
Chemical_Nomenclature : octacosan-1-ol
Canonical SMILES : CCCCCCCCCCCCCCCCCCCCCCCCCCCCO
InChI : InChI=1S\/C28H58O\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29\/h29H,2-28H2,1H3
InChIKey : CNNRPFQICPFDPO-UHFFFAOYSA-N
Other name(s) : 1-Octacosanol || Montanyl alcohol
MW : 410.8
Formula : C28H58O
CAS_number : 557-61-9
PubChem : 68406
UniChem : CNNRPFQICPFDPO-UHFFFAOYSA-N
Target
Families : Octacosanol ligand of proteins in family
Pancreatic_lipase
Protein :
human-PNLIP
References (4)
| Title : Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase - Dong_2025_J.Agric.Food.Chem__ |
| Author(s) : Dong X , Wen Y , Nie Q , Shan S , Zhao R , El-Seedi HR , Zhao C , Zhai Y |
| Ref : Journal of Agricultural and Food Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Dong_2025_J.Agric.Food.Chem__ |
| PubMedID: 40088161 |
| Title : Enzymatic Synthesis of a Novel Antioxidant Octacosanol Lipoate and Its Antioxidant Potency in Sunflower Oil - He_2024_J.Agric.Food.Chem_72_21781 |
| Author(s) : He WS , Zhao L , Sui J , Li X , Huang S , Ding H , Zhu H , Chen ZY |
| Ref : Journal of Agricultural and Food Chemistry , 72 :21781 , 2024 |
| Abstract : |
| PubMedSearch : He_2024_J.Agric.Food.Chem_72_21781 |
| PubMedID: 39289871 |
| Title : Improving Effect of the Policosanol from Ericerus pela Wax on Learning and Memory Impairment Caused by Scopolamine in Mice - Sun_2022_Foods_11_ |
| Author(s) : Sun L , Li X , Ma C , He Z , Zhang X , Wang C , Zhao M , Gan J , Feng Y |
| Ref : Foods , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Sun_2022_Foods_11_ |
| PubMedID: 35885338 |
| Title : New lipoxygenase and cholinesterase inhibitory sphingolipids from Carthamus oxyacantha - Dilshad_2015_Nat.Prod.Res__1 |
| Author(s) : Dilshad M , Riaz N , Saleem M , Shafiq N , Ashraf M , Ismail T , Rafiq HM , Jabbar A |
| Ref : Nat Prod Res , :1 , 2015 |
| Abstract : |
| PubMedSearch : Dilshad_2015_Nat.Prod.Res__1 |
| PubMedID: 26285908 |