PM20
Covalent irreversible inhibitor. Inhibits African malaria mosquito AChE with bimolecular inhibition rate constants (k(inact)/K(I)) of 3,604-458,597 M(-1)sec(-1) but spared human AChE. In comparison, the insecticide paraoxon irreversibly inhibited mosquito and human AChEs with k(inact)/K(I) values of 1,915 and 1,507 M(-1)sec(-1), respectively
General
Type : Pyridine, Pyridinium, Alkyl linked bis-ligand
Chemical_Nomenclature : 1-(20-pyridin-1-ium-1-ylicosyl)pyrrole-2,5-dione bromide
Canonical SMILES : C1=CC=[N+](C=C1)CCCCCCCCCCCCCCCCCCCCN2C(=O)C=CC2=O.[Br-]
InChI : InChI=1S\/C29H47N2O2.BrH\/c32-28-22-23-29(33)31(28)27-21-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-18-24-30-25-19-17-20-26-30\;\/h17,19-20,22-23,25-26H,1-16,18,21,24,27H2\;1H\/q+1\;\/p-1
InChIKey : MMVMMKMTJRLVOK-UHFFFAOYSA-M
Other name(s) : 1-(20-(2,5-dioxo-2,5-dihydro-1h-pyrrol-1-yl)eicosyl)pyridinium bromide || 1-(20-pyridin-1-ium-1-ylicosyl)maleimide bromide || (1-(20-Pyridin-1-ium-1-ylicosyl)pyrrole-2,5-dione)
MW : 535.6
Formula : C29H47BrN2O2
CAS_number :
PubChem : 129891625, 129891626
UniChem : MMVMMKMTJRLVOK-UHFFFAOYSA-M
Target
Families : PM20 ligand of proteins in family
ACHE
Protein :
anoga-ACHE1
References (1)
| Title : Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases - Dou_2013_Sci.Rep_3_1068 |
| Author(s) : Dou D , Park JG , Rana S , Madden BJ , Jiang H , Pang YP |
| Ref : Sci Rep , 3 :1068 , 2013 |
| Abstract : |
| PubMedSearch : Dou_2013_Sci.Rep_3_1068 |
| PubMedID: 23323211 |