PPARd-sEH-Cpd30
IC50 microM PPARdelta 0.12+/-0.02 sEH 0.46+/-0.06
General
Type : Multitarget, Trifluoro, PPARdelta ligand
Chemical_Nomenclature :
Canonical SMILES : OC(CCC2=CC=C(OCCNC(NC1=C(C)C=C(C(F)(F)F)C=C1)=O)C=C2)=O
InChI : InChI=1S\/C20H21F3N2O4\/c1-13-12-15(20(21,22)23)5-8-17(13)25-19(28)24-10-11-29-16-6-2-14(3-7-16)4-9-18(26)27\/h2-3,5-8,12H,4,9-11H2,1H3,(H,26,27)(H2,24,25,28)
InChIKey : MYVFDPWKBRGMNO-UHFFFAOYSA-N
Other name(s) : Compound 30
Target
Families : PPARd-sEH-Cpd30 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Development of Potent and Selective Dual PPAR\/sEH Modulators from an AI-Designed Scaffold - Ge_2025_J.Med.Chem__ |
| Author(s) : Ge X , Kasch T , Lewandowski M , Weizel L , Marschner JA , Pabel J , Proschak E , Merk D |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ge_2025_J.Med.Chem__ |
| PubMedID: 40966045 |